Massive reaction to clopidogrel and pravastatin

[Bess1234]

I had a TIA I was put on pravastatin and clopidogrel. After a few day I started with flue like symptoms but no temperature. Really bad pains in my joints and muscles, skin sore to touch, tireness and massive headache . BP was raised 160/ 80 to 166/70 . I stopped the clopidogrel and started taking aspirin instead. My joint pains have improved and my BP is around 130/ 77. Still have a slight headache. Could the two drugs have interacted with one another to cause these symptoms. That I couldn't tolerate.

[Kirk5w7]

There is a website you can use to check interaction of medication but your GP should have done that before prescribing i know mine does.

[L0ttie]

Hi I had similar muscle aches when I was put on clopidigrel and a statin. I stopped the statin and aches disappeared. Been on clopidigrel since 2017 with no issues. Your GP won’t be happy if you stop a statin but stick to your guns if you think it’s giving you a side effect - unless there is a vital clinical reason you’re on them. They put everyone on statins after a stroke and not always clinically necessary. Depends on cause of your TIA of course.

[Docksgirl]

I am on edoxoban and a 20g statin. I had a stroke but did not suffer too much.Was surprised to be told it was a full stroke and not a a TIA. My cholesterol is now normal. I could not tolerate a higher statin 50g. Did your GP suggest something lower. Hope you are feeling better now. X