Metformin: Does metformin have a cancer... - Diabetes India

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Metformin

ALOPAULA
ALOPAULA

Does metformin have a cancer causing compound as claimed by Dr Scott Olson

17 Replies
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Where di this story come from?

"Laboratory analysis of metformin products

FDA continues to investigate the presence of the N-Nitrosodimethylamine (NDMA) impurity in metformin approved for sale in the U.S. Metformin is a prescription drug used to control high blood sugar in patients with type 2 diabetes. FDA testing has found NDMA in certain lots of extended release (ER) metformin and is recommending companies recall lots with levels of NDMA above the acceptable intake limit of 96 nanograms per day.

FDA is posting its laboratory results in the table below showing NDMA amounts in metformin products it tested. FDA is also collaborating with international regulators to share testing results for metformin.

For reference, consuming up to the acceptable daily intake limit, 0.096 micrograms (96 nanograms), of NDMA per day is considered reasonably safe for human ingestion based on lifetime exposure. NDMA may increase the risk of cancer if people are exposed to it above the acceptable level and over a long period of time, but a person taking a drug that contains NDMA at-or-below the acceptable daily intake limit every day for 70 years is not expected to have an increased risk of cancer."

fda.gov/drugs/drug-safety-a....

ALOPAULA
ALOPAULA
in reply to sandybrown

Thanks a lot

Fatbuddy
Fatbuddy
in reply to sandybrown

Wow..my sweet friend. Very good info

ALOPAULA
ALOPAULA
in reply to sandybrown

I take MSDPHARMACEUTICALS not coming in attached list for janumet

namaha
namahaAdministrator

Some particular batch of Metformin ER seem to have Nitrosodimethylamine (NDMA) ....

I presume all members are taking Metformin IR .... NO one takes ER.... IR is immediate release ..... ER is extended release....

Metformin ER 1000 mg is taken once in a day as against Metformin IR500 mg twice daily.

Metformin ER tablet is a bit complex with coating of dual hydrophilic polymer matrix system in the tablet which delays the release of Metformin . ..

In fact for some people Metformin ER could cause stomach pain since the tablet remain undissolved for a longer duration in the day...

sandybrown
sandybrown
in reply to namaha

Do many members know the difference between Metformin ER and Metformin IR?

When Metformin is prescribed do doctors give explanation in the difference between the two and many side effects?

Thank you for the above explanation.

ALOPAULA
ALOPAULA
in reply to namaha

Thanks for clarifying

sandybrown
sandybrown
in reply to namaha

After my retirement I did many medial on line course, there was one on medication , dosage and release with time graph.

We all need to understand what happens to the pill when it hits the stomach!!

Thank you.

ALOPAULA
ALOPAULA
in reply to sandybrown

Is janumet immediate release or extended can u pl clarify

sandybrown
sandybrown
in reply to ALOPAULA

There are many different type, which type of medication are you taking at the moment?

ALOPAULA
ALOPAULA
in reply to sandybrown

i take janumet 50/1000 twice daily a combination of stigaliptin and metformin

ALOPAULA
ALOPAULA
in reply to sandybrown

Janumet 50/1000 twice daily combination of stigaliptin and metformin

sandybrown
sandybrown
in reply to ALOPAULA

Hi,

I am afraid you need to consult a doctor to get the correct answer, the medication paper work can provide answers as well.!!!

"Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions."

ALOPAULA
ALOPAULA
in reply to sandybrown

I AM TRYING TO REDUCE USE ASDOCTOR ADVISED 50/500 IN MORNING AND 50/1000 AT NIGHT MY PP IS 104 AND FASTING 113 WITH FINGER PRICK IT WILL BE 10-15% LOWER IN LAB HBA1C IS 6 TO AVOID HYPOGLYCEMIA THANKS FOR THE NOTE

sandybrown
sandybrown
in reply to ALOPAULA

HI,

You may have to have a discussion with your doctor on Dosage.

Fatbuddy
Fatbuddy
in reply to ALOPAULA

Janumate --have stomach ache --side effects -- i had stopped afwr 30 days.

Fatbuddy
Fatbuddy
in reply to namaha

In USA, i recoomend -- ER 500 mg --insurance cost much less

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