Metformin

[ALOPAULA]

Does metformin have a cancer causing compound as claimed by Dr Scott Olson

[sandybrown]

Where di this story come from?

"Laboratory analysis of metformin products

FDA continues to investigate the presence of the N-Nitrosodimethylamine (NDMA) impurity in metformin approved for sale in the U.S. Metformin is a prescription drug used to control high blood sugar in patients with type 2 diabetes. FDA testing has found NDMA in certain lots of extended release (ER) metformin and is recommending companies recall lots with levels of NDMA above the acceptable intake limit of 96 nanograms per day.

FDA is posting its laboratory results in the table below showing NDMA amounts in metformin products it tested. FDA is also collaborating with international regulators to share testing results for metformin.

For reference, consuming up to the acceptable daily intake limit, 0.096 micrograms (96 nanograms), of NDMA per day is considered reasonably safe for human ingestion based on lifetime exposure. NDMA may increase the risk of cancer if people are exposed to it above the acceptable level and over a long period of time, but a person taking a drug that contains NDMA at-or-below the acceptable daily intake limit every day for 70 years is not expected to have an increased risk of cancer."

fda.gov/drugs/drug-safety-a....

[ALOPAULA in reply to sandybrown]

Thanks a lot

[ALOPAULA in reply to sandybrown]

I take MSDPHARMACEUTICALS not coming in attached list for janumet

[namaha Administrator]

Some particular batch of Metformin ER seem to have Nitrosodimethylamine (NDMA) ....

I presume all members are taking Metformin IR .... NO one takes ER.... IR is immediate release ..... ER is extended release....

Metformin ER 1000 mg is taken once in a day as against Metformin IR500 mg twice daily.

Metformin ER tablet is a bit complex with coating of dual hydrophilic polymer matrix system in the tablet which delays the release of Metformin . ..

In fact for some people Metformin ER could cause stomach pain since the tablet remain undissolved for a longer duration in the day...

[sandybrown in reply to namaha]

Do many members know the difference between Metformin ER and Metformin IR?

When Metformin is prescribed do doctors give explanation in the difference between the two and many side effects?

Thank you for the above explanation.

[ALOPAULA in reply to namaha]

Thanks for clarifying

[sandybrown in reply to namaha]

After my retirement I did many medial on line course, there was one on medication , dosage and release with time graph.

We all need to understand what happens to the pill when it hits the stomach!!

Thank you.

[ALOPAULA in reply to sandybrown]

Is janumet immediate release or extended can u pl clarify

[sandybrown in reply to ALOPAULA]

There are many different type, which type of medication are you taking at the moment?

[ALOPAULA in reply to sandybrown]

i take janumet 50/1000 twice daily a combination of stigaliptin and metformin

[ALOPAULA in reply to sandybrown]

Janumet 50/1000 twice daily combination of stigaliptin and metformin

[sandybrown in reply to ALOPAULA]

Hi,

I am afraid you need to consult a doctor to get the correct answer, the medication paper work can provide answers as well.!!!

"Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions."

[ALOPAULA in reply to sandybrown]

I AM TRYING TO REDUCE USE ASDOCTOR ADVISED 50/500 IN MORNING AND 50/1000 AT NIGHT MY PP IS 104 AND FASTING 113 WITH FINGER PRICK IT WILL BE 10-15% LOWER IN LAB HBA1C IS 6 TO AVOID HYPOGLYCEMIA THANKS FOR THE NOTE

[sandybrown in reply to ALOPAULA]

HI,

You may have to have a discussion with your doctor on Dosage.