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Coccinia indica (ivy gourd) is a creeper that grows widely in India and Bangladesh. The plant has been used since ancient times as an antidiabetic drug by physicians who practice Ayurveda. A double-blind control trial (n = 32), conducted in India, demonstrated significant improvement in glycemic control following 6 weeks’ use of powder from locally obtained crushed dried leaves of Coccinia indica in patients with poorly controlled or otherwise untreated type 2 diabetes; however, there were no data available regarding whether body weight changed (7). In another three-arm, controlled clinical trial (n = 70), the use of dried herb pellets made from fresh leaves of Coccinia indica was compared with no treatment and treatment with oral hypoglycemic agents (chlopropamide) (16). The improvement in glycemic control observed in the group that was treated with the herb was similar to that associated with use of a conventional drug.