Rotigotine anyone take there patch off at night ? Anyone been on Rotigotine and stop it for some thing else. WHAT IS IT ?

[export]

Anyone know why Rotigotine was once band in the USA ? Anyone had problems with. ?

I HAVE BLURRED VISION . MY STOMACH LOOK LIKE I AM 9 MONTHS PREGNANT ALSO GOT THE MAN BOOBS WEIGHT INCREASE. CAN'T SLEEP AT NIGHT .

yours EXPORT .

[rons]

I didn't get on with Dopamine Agonists, Rotigotine was the worst not only did I put on 20kgs but they fell off my sweaty body all the time leaving me immobile and hospitalised. In hot hospital they fell off even more and to make it worse were locked away by the nurses so I couldn't slap another on, disaster...

anyway on stalevo now, other side effects but 20kgs have gone away and I'm going to the gym this pm to get into a routine, may even try zumba!

I think it got banned because of adverse reaction to stopping so if you do come off the patches take it slowly.

[export]

Thank for;that

[Brooke]

I srarted using the Neupro patch 2mg last Aug,got up o 8mg. It is very expensive. It did not help me.Now I am almost off it. My movement Dr. says I am a good candidate for DBS. I am considering it.

[landman]

Talk to your Dr and Pharmacist. I am on patch, no problem. When you remove patch clean area with alcohol and sooth with hand creme.

[CathyS in reply to landman]

Were you the one who had a suggestion for getting help paying for the patch? I just got back from the pharmacy - empty handed and with tears in my eyes. 2012 - $50 USD. 2013 - $382!!! I could "save money" however by buying a 3-month supply for $900. I'm trying to find out who it was that mentioned some help from UCB (maybe)

[export]

landman I have no problem with my skin . I am talking about allergic reaction hallucinations not sleeping at night sweating .falling asleep suddenly blurred vision .

My GP said I know more than he dose same with chemist .

yours EXPORT.

PS ron how long did it take to stop them ?

[GrammyC]

I just started using the Neupro patch. I quit after just 2 days. It totally knocked me out! I couldn't get off the couch to do anything and my eyes kept closing even though I was trying to stay awake. It did nothing to help my "stuck to the floor" feet. I am waiting for the doctor to call back with another idea to try. I've been on sinemet for 3 1/2 years and seem to need an adjustment with it.

[export]

Hi Grammy the trouble is they don't have a lot offer you. what else have you tried . The best one I have had is pergolide but it take about 10 weeks to work . starting on migcow grams

Please let me know what the doctor give you.

yours EXPORT.

[export]

Brooke hi do you have to pay for your meds ? where do you live ?

yours EXPORT.

[Brooke]

I live in Florida.I get medicare.The meds arr so expensive that by March I am in the coverage gap and have to pay around 2.000 evry 3 months. I end up getting meds from Canadia pharmacy. I take sinemet azelict an mirapex.

[export]

That the price you pay for living in the sun. What would happen if you had no money ?

Do you work. I am interested how the other half live. If you don't want to answer i will understand .Thanks anyway EXPORT.

[Brooke in reply to export]

I live in a beautiful place The Villages,Fl. I am retired.Even tho I have PD with a lot of off time I do a lot.I line dance,sing in my church choir,shop,visit with friends. I push myself to keep on going. I keep saying I have PD but it does not have me.I believe in the power of prayer and miracles.

[ozepook47]

Rotigotine belongs to a class of drugs called "dopamine agonists". A dopamine agonist is a compound that activates dopamine receptors in the absence of dopamine.This means they "fool" the receptor that dopamine acts upon to produce the same effect but often without the dopamine side effects.However, they do have their own adverse effects. (see later)

Other dopamine agonists are apomorphine, bromocriptine, cabergoline, pergolide, pramipexole, quinagolide, and ropinirole.

Dopamine agonists may increase the adverse effects of other drugs with dopamine agonist activity, eg levodopa; monitor closely and reduce drug dose(s) if required.

They can:

cause hypotension ; administration with other drugs that also cause this may result in an additional drop in blood pressure.

Improve bradykinesia (slow movements) and rigidity, but are less effective than levodopa.

May cause confusion and hallucinations more often than levodopa, especially in elderly or demented people, and in high doses.

Used as monotherapy in early disease, they delay the onset of motor fluctuations and dyskinesias, and may be preferred to levodopa as first-line treatment in younger patients.

Adding a dopamine agonist to levodopa improves motor fluctuations and allows levodopa dose to be reduced.

Common adverse effects are:

application site reactions,

insomnia,

paradoxical worsening of restless legs syndrome

Infrequent adverse effects are:

visual disturbance,

impulse control disorders, eg pathological gambling, (gambling, shopping, internet pornography, hyper-sexuality)

How to get the most benefit from Rotigotine:

Apply at the same time each day to non-irritated, clean, dry, hairless skin on the hip, abdomen, thigh, upper arm or shoulder. When changing the patch, remove the old patch and apply a new one to a different place (avoid applying to the same place for 14 days).

do not cut patches; 2 patches can be applied simultaneously to give doses >8 mg/24 hours

do not stop treatment abruptly; gradually reduce dose over several days

manufacturer recommends regular monitoring by eye specialist (your blurred vision?)

in clinical trials, rotigotine was more effective than placebo in reducing symptoms of early Parkinson's disease and in reducing 'off' time in advanced disease; although it was similar to pramipexole (Sifrol) in reducing 'off' time in advanced levodopa-treated Parkinson's disease, further comparative data are needed

As it is a relatively new medication the long-term safety and efficacy data are lacking.

Dosage

Parkinson's disease

Early stage, initially one 2 mg/24 hours patch applied once daily; increase dose each week by 2 mg/24 hours, as required. Maximum 8 mg/24 hours once daily.

Advanced, initially one 4 mg/24 hours patch applied once daily; increase dose each week by 2 mg/24 hours, as required. Maximum 16 mg/24 hours once daily.

(This information was retrieved from The Australian Medicines Handbook (Jan 2013) so is up-to-date. The AMH is one of several references that all Australian pharmacists must have in their reference library).