Statins/NSAIDs slow progression?

[tomstuff]

This came out today...

parkinsonsnewstoday.com/new...

"When statins or NSAIDs were used after Parkinson’s symptoms had begun, patients still experienced a significant delay in disease onset compared with those who had never taken them, although to a lesser degree than when the medications were taken before symptom onset. Statins resulted in a delay of 3.8 years, while NSAIDs delayed onset by 2.7 years."

[Gcf51]

I use to take a couple of Advil every night, but my doctor says bad for my kidney function, so I stopped.

[park_bear]

Caution - these are associations which are not the same as causation. In the case of statins, patients taking statins can be expected to have higher cholesterol. It may be that high cholesterol has a protective effect. Also here is a different study that found statin usage to be adverse: pubmed.ncbi.nlm.nih.gov/283...

Statins may facilitate Parkinson’s disease: Insight gained from a large, national claims database

"Results—Statin usage was significantly associated with PD risk, with the strongest associations being for lipophilic (OR=1.58, p<0.0001) vs. hydrophilic (OR=1.19, p=0.25) statins, statins plus non-statins (OR=1.95, p<0.0001), and for the initial period after starting statins (<1 y OR=.82, 1–2.5 y OR =1.75, and ≥2.5 y OR =1.37; ptrend<0.0001).

Conclusion—Use of statin (especially lipophilics) was associated with higher risk of PD, and the stronger association in initial use suggests a facilitating effect"

[Bracondale in reply to park_bear]

Totally agree, correlation/association is not necessarily causation. I think that statins may have a 'protective' effect in that I understand them to be 'anti-inflammatory' effects. But I also understand that cholesterol is raised as a protective response if inflammation in the body is increased. Typical allopathic ideology, to treat something that is undesirable by trying to quell it, rather than consider why our bodies might try to raise it. Of course it is profitable for the pharm companies if high cholesterol is considered to be pathological. Killing the firefighters attending a blaze comes to mind here!

[Jbeaner in reply to Bracondale]

Love your analogy.

[Bracondale in reply to Jbeaner]

Thank you...it's not original, but I loved it too 😊

[Bracondale]

I guess that they are both acting via their anti-inflammatory effect. In the case of statins though, this is at the expense of C0Q10 production which will have an effect on energy production in every cell in the body. The question is, what is causing the inflammation in the first place.

[Spike_777]

It's my opinion that statins are profoundly bad for you, watch some videos on YouTube for a better explanation why than I can give.

And my experience with NSAIDs is if you take them for more than a week or so they start to work against you, and you get aches & pains and feel generally worse.