this is a topic which has been discussed before, but there is a new video on YouTube about it.
Unfortunately, I can’t link to it (I hope somebody can tell me how to copy and paste the links on my phone), but if you search for the video on Parkinson’s disease education channel, you should find it
youtu.be/Jo2DgYtOVFc?si=ai_...
Is this the one?
When Dr Sackner-Bernstein visited this site I asked him how dopamine could be the problem when a number of genetic mutations affecting alpha synuclein are known to cause Parkinson's. He had no answer.
It could be interesting to stay undercorrected with dopamine and do a lot of physical exercises in order to exploit the plasticity of the brain to try to move better through new pathways. In this way, dyskinesias are reduced.
I did try that when I was first diagnosed. But I did not really keep up the level of exercise. I have never liked serious exercise or sport but am not inactive.
It probably helped my balance.
If his trial goes ahead, then I guess we’ll know then if he is on to something or not
If anyone is interested Jonathan Sackner Bernstein has a website (rightbrainbio.com/) where you can subscribe to his blog.
I guess we will see, but people with a confirmed conflict of interest in proving their theory tend to have pressures in selection, size, method, oversight, etc. and he sounds like a practitioner rather than a researcher so there is no implied ability in training (and ethical devotion to validity) as a scientist to work against conscious and unconscious bias in experiment design and evaluation. Witness the 100-120 million that guy at Harvard Medical School made off of the fraudulent research he conducted in this lab on reservatrol, creating his own company on the hype of what I think I was his intentionally bogus mercantile research pitch and then selling it.
Call me obtuse, but if less dopamine is the answer, shouldn't we all feel great?? Disclosure - I did not watch the video.
That's what I was thinking...in the five years from my diagnosis to start of mucuna and c/l, wouldn't my tremor and rigidity have fixed itself?
Yeah, the guy seems smart but if his theory is true, testing on a single patient should have the reverse effect of what mainstream medicine supposes. I know it's very complicated, but if he's right, it's vital. Is there really no way in the world to just "find out" whether his idea is real, just for himself or single individuals who *know* privately whether or not it works, and go from there?
Is Thiamine really stoping the progression of PD!?
Less sinemet more often 
change in meds, pd progression
Daily pill could halt effects of Parkinson’s, scientists suggest
Rate of Progression.
