B1 thiamine question

[Discogs_discogs]

High dose vitamin B1 thiamine has been amazing at alleviating my muscle stiffness, but I'm increasingly finding that it wears off 25% by midnight and about 50% by the next morning when I wake up, at least until I take my first dose. How do you cope with this?

My question: Doesn't an extended release form of vitamin B1 exist? If so, that could alleviate my B1 "wearing off" problem.

DOSE:

My dose is 2500 MG HCL broken up into intervals throughout the day, but never after 5pm to avoid sleep disturbance. I also take sublingual B1 mononitrate 10 mg morning and 10mg early afternoon. Maybe I have outgrown my dose and need to increase it because my body is getting too used to it and the disease is progressing. Nobody takes as much as 8000 MG thiamine HCL per day, do they?

[Dap1948]

if anything your dose is now too high. It certainly sounds very high. I suggest you take a 1-2 week break checking that your symptoms improve which would show that the dose is now too high.

I also suggest that you join our facebook group, where you would get on going support.

facebook.com/share/g/153KLy...

You don’t need to feed yourself on going B1 through the day and night. I only take mine once a week!

Hopefully you can open this link which explains what B1 is doing.

facebook.com/share/p/166L4U...?

[Discogs_discogs in reply to Dap1948]

This is very helpful information. Thank you, Daphne.

Do you know whether the intramuscular type of thiamine is known to last longer in a person's system? I have not tried it and I don't even know where to buy it. Nor would I know how to inject it, but that's another topic altogether. I will check out the web links that you posted for more info.

I actually just took a one month break from vitamin B1 recently and my symptoms got worse as a result. At the same time, I had stopped exercising for about 5 months, which was likely a contributing factor to my sudden increase in symptoms. I regret having stopped B1 for a month because, if I had not done so, I feel that my PD would not have progressed during that interval. Two weeks of a nasty flu during my B1 break may have contributed as well.

Part of the problem might also be that I naturally have a very high metabolism. I've been taking high-dose vitamin B1 for a few years and never before felt that it was wearing off at night or the next morning. This is new for me. Perhaps the thiamine is just building up in my system again after taking a month-long break from B1.

In hindsight, I should only have taken a week off from B1 because a week would not have set me back, even for a person with a very high metabolism like myself.

Prior to taking a protracted break, my usual dose had been 2000 milligrammes of thiamine HCL per day, supplemented by the occasional sublingual dose. That dosage has worked magic for the past couple of years, right up until my recent break.

[Dap1948 in reply to Discogs_discogs]

I’ve read that any form of thiamine can last for up to 18 days in the body.

Most people find that their B1 doses need to be reduced over time. Over the last seven years I have reduced my B1 dosage from 100 mg sublingual per day to 3,125 mg per week.