Glutathione

[ghoegap]

Some years ago there was alot said about intranasal glutathione. Is it received wisdom that all oral glutathione is a waste of time?

[gaga1958]

this is the one i use......aurowellness.com/

you rub 4 drops on the skin, stinks tho

[Bolt_Upright in reply to gaga1958]

Have you noticed any benefits? Benefits may not mean improvements, but non progression or slowing of progression.

[gaga1958 in reply to Bolt_Upright]

as typical i take so many things, its hard to know but on avg, i have progressed slower than typical

[ghoegap in reply to gaga1958]

Thanks info!

[park_bear]

I tried inhaling nebulized glutathione for some weeks. Did not seem to do anything for me.

[Edge999]

I take oral glutathione occasionally. Its not doing anything bad but difficult to tell if it helps or does anything

[SuuSuu]

I was in Laurie Mischley's 2015 nasal glutathione study. I noticed significant improvements. Following the study I have continued with oral NAC or more recently glutathione and notice an increase in stiffness, rigidity or slowness if I stop. Glutathione is one of the few supplements that give me observable benefits.

[ghoegap in reply to SuuSuu]

Thanks! And now you use oral glutathione?

[Bluebell2022 in reply to SuuSuu]

What was the name of the intranasal you used, is it available to buy?

[SuuSuu]

Yes... NAC is cheaper but L Mischleyy insists the cystine in NAC is bad... they seem to work the same for me, but I respect her advice and usually use glutathione (oral).

[octonaut in reply to SuuSuu]

SuuSuu, what glutathione do you use? I've been using a rather pricey Lypo-Spheric Glutathione made by LivOn. It's fussy to take -- squeeze a packet into an ounce of water and slug it down quick. I'd rather take a capsule, as long as absorption is equivalent. .. side-note: I DID see that Laurie Mischley is negative on NAC, so I removed that from my stack. Haven't seen a specific recommendation from her on glutathione as yet. Any insight appreciated; thank you kindly.

[SuuSuu in reply to octonaut]

Mischley said that based on responses to her research the cheapest (I think she references Jarrow) is as effective as the more expensive. I usually use NOW 500mg but have also used Drs Best and Jarrow. I've never used liposomal.

[SuuSuu]

It was a special formulation for the study. You could ask Laurie... My MDS spoke to Mischley and prescribed 30 days intranasal for me a few months after the study... it was close to $300 (in 2016) and I didn't see much difference than the oral NAC I was taking at that time. The study was inconclusive overall, but for ME it had significant impact.

[Peter-Jan]

Researcher Rajagopal V. Sekhar specializes in glutathione. In this article mdpi.com/2072-6643/14/5/1114 he writes: “No studies have reported an increase in mammalian lifespan by supplementing exogenous glutathione. On the contrary, supplementation of exogenous GSH was found to accelerate aging and shorten life in C. elegans”.

He has better results when using GlyNAC, in the same article he writes: “Because different organs maintain different concentrations of GSH, providing exogenous GSH is associated with the risk of inducing reductive stress. GlyNAC avoids this problem by allowing cells to autoregulate and maintain their required GSH homeostasis, i.e., GlyNAC does not interfere with cellular autoregulation whereby cells make the requisite amount of GSH based on cellular need”.

There is also a clinical study: onlinelibrary.wiley.com/doi.... What appeals to me is that all those improvements such as improves glutathione deficiency, and less oxidative stress etc. is also of great importance in PD. I have been using GlyNAC for a week now.

[Chicoman in reply to Peter-Jan]

What’s the difference in GYLNAC and NAC

[Peter-Jan in reply to Chicoman]

GlyNAC is the combination of Glycine and NAC. In this study (academic.oup.com/biomedgero... the formula for the dose is 100 mg/kg/d each of glycine and NAC.

[Missy0202]

I take liposomal glutathione made by designs for health. I dont see noticeable improvements but I will continue to take it.

[Bracondale]

My understanding is that the liposomal form is much better absorbed than ordinary glutathione. I definitely noticed more energy after some initial headaches (I don't have PD). This is the one that I used which was pleasantly fruity flavoured unlike the sulphurous tasting others that I'd tried.

amazon.co.uk/Intelligent-La...

It can mobilise heavy metals, so be cautious if you have any mercury amalgam fillings. (I did, but didn't notice any adverse effects.)