Norepinephrine loss produces more profound motor deficits than MPTP treatment in mice

[Bear1927]

Interesting topic: pubmed.ncbi.nlm.nih.gov/177...

Results of this experiment suggest that loss of locus coeruleus neurons contributes to motor dysfunction in PD.

Norepinephrine Deficiency in Parkinson's Disease: The Case for Noradrenergic Enhancement

researchgate.net/publicatio...

Growing evidence supports earlier norepinephrine (NE) deficiency resulting from selective degeneration of neurons of the locus coeruleus and sympathetic ganglia. Dopaminergic replacement therapy therefore would seem to neglect some of the motor, behavioral, cognitive, and autonomic impairments that are directly or indirectly associated with the marked deficiency of NE in the brain and elsewhere.