Forskolin

[JayPwP]

An offshoot from   LAJ12345  post here healthunlocked.com/cure-par...

Found the following:

Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats

ncbi.nlm.nih.gov/pmc/articl...

[park_bear]

This study casts doubts upon Pink1 as a valid model of Parkinson's:

academic.oup.com/braincomms...

[LAJ12345]

Seems it’s used for weight loss amongst a lot of other things so probably not the best thing for people struggling to keep weight on.

pubmed.ncbi.nlm.nih.gov/161...

“Discussion: Oral ingestion of forskolin (250 mg of 10% forskolin extract twice a day) for a 12-week period was shown to favorably alter body composition while concurrently increasing bone mass and serum free testosterone levels in overweight and obese men. The results indicate that forskolin is a possible therapeutic agent for the management and treatment of obesity.”

examine.com/supplements/col...

”Coleus forskohlii is an herb historically used in Ayurveda (Ayurvedic medicine). Today, Coleus forskohlii is used as a fat burning supplement.The main bioactive ingredient in Coleus forskohlii is called forskolin. Through forskolin, Coleus forskohlii supplementation may increase testosterone, and protect against cancer and inflammation. Further research is needed to confirm these effects, since forskolin is most often used as a research tool in vitro, or outside the body, like in a test tube or petri dish. Forskolin may act differently inside the body.Forskolin increases cellular levels of a molecule called cyclic adenosine monophosphate (cAMP). Elevated cAMP levels are associated with increased rates of fat loss, and can improve the effects of other fat burning compounds.Forskolin is still being researched for its effects on testosterone and fat loss, but preliminary evidence is promising.”

nz.iherb.com/r/nature-s-way...

This seems to have the same dose at 125mg of 20% twice a day.

for under active thyroid pubmed.ncbi.nlm.nih.gov/632...

[Bolt_Upright in reply to LAJ12345]

Boosts testosterone, lowers inflammation, helps with under-active thyroid. worth researching. Thank for the details.

[Raphaekg]

Please remember that the structure of dopaminergic neurons in rats is different from the structure in humans. We have dopaminergic neurons with neuromelanin. Only humans (and to a lesser degree, our closest mammalian relatives,) have this unique structure. I suspect that this is why translation of rodent studies to humans is so poor.

[LAJ12345 in reply to Raphaekg]

yes it doesn’t look like many human trials have been done

[Raphaekg in reply to LAJ12345]

None for PD. And none planned according to clinicaltrials.gov .

[Bolt_Upright]

They need to come up with a better name than "Forskolin"

[LAJ12345 in reply to Bolt_Upright]

🤣

[Bolt_Upright]

Great paper on Forskolin: Restoration of Mitochondrial Dysfunction in 6-Hydroxydopamine Induced Parkinson's disease: a Complete Review researchgate.net/publicatio...

[LAJ12345 in reply to Bolt_Upright]

in rats again. Hope they do some human trials