Forskolin: An offshoot from   LAJ1234... - Cure Parkinson's

Cure Parkinson's

25,340 members26,641 posts

Forskolin

JayPwP profile image
10 Replies

An offshoot from   LAJ12345  post here healthunlocked.com/cure-par...

Found the following:

Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats

ncbi.nlm.nih.gov/pmc/articl...

Written by
JayPwP profile image
JayPwP
To view profiles and participate in discussions please or .
Read more about...
10 Replies
park_bear profile image
park_bear

This study casts doubts upon Pink1 as a valid model of Parkinson's:

academic.oup.com/braincomms...

LAJ12345 profile image
LAJ12345

Seems it’s used for weight loss amongst a lot of other things so probably not the best thing for people struggling to keep weight on.

pubmed.ncbi.nlm.nih.gov/161...

“Discussion: Oral ingestion of forskolin (250 mg of 10% forskolin extract twice a day) for a 12-week period was shown to favorably alter body composition while concurrently increasing bone mass and serum free testosterone levels in overweight and obese men. The results indicate that forskolin is a possible therapeutic agent for the management and treatment of obesity.”

examine.com/supplements/col...

”Coleus forskohlii is an herb historically used in Ayurveda (Ayurvedic medicine). Today, Coleus forskohlii is used as a fat burning supplement.The main bioactive ingredient in Coleus forskohlii is called forskolin. Through forskolin, Coleus forskohlii supplementation may increase testosterone, and protect against cancer and inflammation. Further research is needed to confirm these effects, since forskolin is most often used as a research tool in vitro, or outside the body, like in a test tube or petri dish. Forskolin may act differently inside the body.Forskolin increases cellular levels of a molecule called cyclic adenosine monophosphate (cAMP). Elevated cAMP levels are associated with increased rates of fat loss, and can improve the effects of other fat burning compounds.Forskolin is still being researched for its effects on testosterone and fat loss, but preliminary evidence is promising.”

nz.iherb.com/r/nature-s-way...

This seems to have the same dose at 125mg of 20% twice a day.

for under active thyroid pubmed.ncbi.nlm.nih.gov/632...

Bolt_Upright profile image
Bolt_Upright in reply to LAJ12345

Boosts testosterone, lowers inflammation, helps with under-active thyroid. worth researching. Thank for the details.

Raphaekg profile image
Raphaekg

Please remember that the structure of dopaminergic neurons in rats is different from the structure in humans. We have dopaminergic neurons with neuromelanin. Only humans (and to a lesser degree, our closest mammalian relatives,) have this unique structure. I suspect that this is why translation of rodent studies to humans is so poor.

LAJ12345 profile image
LAJ12345 in reply to Raphaekg

yes it doesn’t look like many human trials have been done

Raphaekg profile image
Raphaekg in reply to LAJ12345

None for PD. And none planned according to clinicaltrials.gov .

Bolt_Upright profile image
Bolt_Upright

They need to come up with a better name than "Forskolin" :)

LAJ12345 profile image
LAJ12345 in reply to Bolt_Upright

🤣

Bolt_Upright profile image
Bolt_Upright

Great paper on Forskolin: Restoration of Mitochondrial Dysfunction in 6-Hydroxydopamine Induced Parkinson's disease: a Complete Review researchgate.net/publicatio...

LAJ12345 profile image
LAJ12345 in reply to Bolt_Upright

in rats again. Hope they do some human trials

You may also like...

'Reverse Parkinson' by breathing-in Farnesol with a humidifier?

both significantly prevented the loss of dopamine neurons and reversed behavioral...

High-intensity Exercise Can Reverse Neurodegeneration in Parkinson’s Disease

exercise, the neurons actually had grown healthier and produced stronger dopamine signals. Dopamine...

Levodopa May Reduce Neuroinflammation

Parkinson’s disease that increases dopamine in the brain was found to reverse the effects of...

How many with PD (have taken or does take) Tyrosine

detrimental effect on PD....

Covid 19 may infect dopamine neurons

this article is in Neuroscience News and I guess this did not seem surprising to me...