Intermittent hypoxia (low oxygen therapy)?

[AkunaMatata]

Has anyone tried intermittent hypoxic therapy?

After many reports of improvements of PD symptoms at high altitude, there is an ongoing trial in the Netherlands sponsored by the Michael J Fox Foundation: Randomized controlled trial of intermittent hypoxia in Parkinson’s disease: study rationale and protocol: bmcneurol.biomedcentral.com...

"The intervention will be primarily administered at the participant’s home. Therefore, the generator is modified in collaboration with the manufacturer, such that the device automatically titrates the correct fraction of inspired oxygen (FIO2) of 0.16 in a closed feedback loop with an FIO2 sensor, and automatically regulates the intervention per protocol (five times five minutes hypoxia interspersed with five minutes of normoxia, totaling 45 min).”

They use this device (€2,783.00): altitude-training-webshop.c...

These papers explain the rationale behind the potential benefits of hypoxia in PD and other neurodegenerative diseases:

mdpi.com/1422-0067/25/3/1759

drive.google.com/file/d/1Dr...

journals.sagepub.com/doi/fu...

researchgate.net/publicatio...

Some clinics & spas also offer hypoxia therapy sessions.

Could hypoxia explain the protective effects of exercise, altitude, smoking, asthma, and anemia found in several PD studies?

[Boscoejean]

It will be interesting to see the results

[michelagvolpe]

Michel J Fox wrote in his biography that at high altitudes where there was little oxygen he felt better. In reality he probably felt better because he was relaxed in Bhutan, the paradise of happiness. The Dutch researcher Bloem has obtained funding to correlate hypoxia and parkinson's from the MJF foundation

michaeljfox.org/grant/hypox...

To this day everything is still pending. Money received!

Hypoxia damages the brain. I who did freediving training in water for many years, stopped because when the apnea was too long, the tremors worsened.

[AkunaMatata in reply to michelagvolpe]

Yes, the research is funded by the MJFF. They concluded the Phase 1 and showed it was safe. They've just finished the Phase 2 and we're waiting for the results.

Extreme hypoxia does damage the brain. But it seems that moderate intermittent hypoxia is good for the brain: Effects of Intermittent Hypoxia Protocols on Cognitive Performance and Brain Health in Older Adults Across Cognitive States: A Systematic Literature Review ( journals.sagepub.com/doi/fu... ).

Even chronic hypoxia at mild altitudes seems protective: Association Between Alzheimer Dementia Mortality Rate and Altitude in California Counties ( jamanetwork.com/journals/ja... ): "In age-adjusted models, each doubling in altitude was associated with a roughly 2-point decline in the age-adjusted mortality rate for dementia."

[JayPwP]

healthunlocked.com/cure-par...

[AkunaMatata in reply to JayPwP]

Thanks. I saw your thread before posting: have you tried it?

[JayPwP in reply to AkunaMatata]

On and off. Nothing consistently.

[AkunaMatata in reply to JayPwP]

What was your protocol? (how many min of hypoxia at which FiO2 and how many cycles) And did you notice anything positive or negative during and after the sessions?