Intermittent Hypoxia for Parkinson's disease PD - Benefit or Harm

[JayPwP]

Research seems mixed. As it is, most breathing techniques involve some sort of Hypoxia whether it is box breathing, 4-7-8, 4-16-8, etc.

Posting some links for the same

[JayPwP]

Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?”

ncbi.nlm.nih.gov/pmc/articl...

[JayPwP]

The effects of chronic intermittent hypoxia on dopaminergic neurodegeneration

erj.ersjournals.com/content...

[JayPwP]

Parkinson’s disease and intermittent hypoxia training: beneficial or harmful?

mdsabstracts.org/abstract/p...

[JayPwP]

Intermittent Hypoxia and Experimental Parkinson’s Disease

link.springer.com/chapter/1...

[Dap1948]

So is it good or bad?! I’ve read some of what you posted but I’m still none the wiser. What do you understand the verdict to be? I’ve been doing the Wim Hof breathing for a few weeks. I can’t say I feel any different!

[JayPwP in reply to Dap1948]

Wim hof breathing uses both, hyperventilation as well as hypoventilation.

To answer your question, I am confused myself

[kaypeeoh in reply to Dap1948]

I'm familiar with Hof. He uses meditation to inure himself to deep cold.

[kaypeeoh]

Just a guess. Exercise is one of the few things known to benefit PD. Exercise requires an elevated heart rate. An elevated heart rate uses oxygen. When leisurely walking the body is using mainly fat for energy. The harder the body is working--by breathing hard--the higher the percentage of sugar being used for energy. Years ago I hired a trainer to help me improve my running. He put me on a stress test treadmill. I wore a mask that captured the CO2 I was expelling. At a leisurely walk my heart rate was 50bpm. I was burning 95% fat. At the other end my heart rate was 185 bpm and I was burning 95% sugar.

I'm sure right now someone is writing the causation/correlation argument. It's known that severe exercise stimulates human growth hormone. Maybe that's a clue.

[sharoncrayn in reply to kaypeeoh]

Continual long term extreme stress, regardless of its origin or type, is not beneficial for slowing the progression of PD. We have discussed this at length before. If it was, individuals such as yourself would not have PD.

Extremely short term hypoxia CTs using rats or humans fail to reach an acceptable level of credibility.

sharon

[Smittybear7]

What about hyperbaric oxygen therapy?

[rebtar]

I wouldn't say that most breathing techniques involve hypoxia. Deep slow breathing into the belly is a technique that slows heart rate and strengthens the Parasympathetic nervous system (rest and digest). Especially if the exhale is longer than the inhale. Also nasal breathing increases oxygen uptake as well as nitric oxide.

My impression (for myself) is that there is a place for hypoxic exercises, but not if your parasympathetic nervous system is in bad shape (true for a lot of people with PD).

healthline.com/health/nose-...

hingehealth.com/blog/7-dail...

[JayPwP in reply to rebtar]

If exhaling is longer than inhaling, it is creating an Hypoxia effect.

[rebtar in reply to JayPwP]

Deep breathing, say breathing in for four seconds and out for six, will allow your body to get into a deeply relaxed state. That can only be good, don't you think? It's helped me to be more relaxed, less anxious, improved heart rate variability. How can that be bad for me?

Here's another link on how longer exhalations affect the vagus nerve...

psychologytoday.com/us/blog...

[JayPwP in reply to rebtar]

I am not questioning the good or bad, I am just saying that depriving the body of Oxygen for a short time is inducing controlled Hypoxia, like wim hof breathing, 3 rounds of 30 breaths of controlled hyperventilation followed by a period of Hypoxia between each round.

[JayPwP]

Nisshesha rechaka pranayama offers benefits through brief intermittent hypoxia

ncbi.nlm.nih.gov/pmc/articl...

Method / Setting b. is what Wim Hof popularized - Hyperventilation followed by empty lung breath hold.

[Stillstandingstill in reply to JayPwP]

Fascinating read. Thank you for sharing.

[JayPwP in reply to Stillstandingstill]

Thanks

[JayPwP]

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

nature.com/articles/s41467-...

[JayPwP]

Oxygen Deficit Makes Nerve Cells Grow

neurosciencenews.com/functi...

[JayPwP]

Hypoxic postconditioning promotes neurogenesis by modulating the metabolism of neural stem cells after cerebral ischemia

sciencedirect.com/science/a...

[JayPwP]

Can yoga therapy stimulate stem cell trafficking from bone marrow

sciencedirect.com/science/a...

7. Conclusions

It is clear from the foregoing account that yoga practice has a potential to induce stem cell trafficking from bone marrow to peripheral blood for possible repair and regeneration of tissues. The literature cited in this review demonstrates the importance of yoga therapy in wellness as well as illness. The rejuvenating and curative effects experienced by yoga practitioners could be attributed to repair and regeneration of tissues by replacement and recruitment of cells differentiated from the stem cell which is beyond the drug action. Therefore, yoga practice can be looked upon as one of the best ways to facilitate stem cell trafficking essential for healthy living and improving the quality of life under the scenario of rise in longevity of human being. However, there is no direct evidence from the literature search to support this idea indicating the need to develop such evidence-based science for yoga.

[SilentEchoes]

I realize this post is a year old but I feel I can shine some light on hypoxia and neurodegeneration. I have a ventilator to regulate my oxygen levels, chronic hypoxia is detrimental to health. Sleep apnea and heart disease for example.

The problem with restrictive lung disease is the buildup of CO2 gas creating an acid/base imbalance. The warning signs are morning headaches and being very drowsy. Holding your breath periodically in this situation will help reset the nervous system. I actually went to the hospital because the wrong therapy (bipap) put me into acidosis, which is like hyperventilating and once you're caught in this cycle it's hard to break, it leads to respiratory failure.

In a nutshell, hypoxia is bad - it causes brain damage.

Slow breathing to reset your nervous system is good - it's not the same as hypoxia.

Everyone should have a sleep study as part of their diagnostic workup for neurodegenerative conditions. Autonomic dysfunction and central apnea are part of the pathology, in my case early intervention can prolong my life.

SE

[JayPwP in reply to SilentEchoes]

Thanks

[JayPwP]

This has to be lístened to entirely

youtu.be/V72L6RH3OD8(Not working as expected?)

[JayPwP in reply to JayPwP]

youtu.be/S1sZNbRH2N8(Not working as expected?)