Intermittent Hypoxia for Parkinson's dise... - Cure Parkinson's

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Intermittent Hypoxia for Parkinson's disease PD - Benefit or Harm

JayPwP profile image

Research seems mixed. As it is, most breathing techniques involve some sort of Hypoxia whether it is box breathing, 4-7-8, 4-16-8, etc.

Posting some links for the same

14 Replies

Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?”

The effects of chronic intermittent hypoxia on dopaminergic neurodegeneration

Parkinson’s disease and intermittent hypoxia training: beneficial or harmful?

Intermittent Hypoxia and Experimental Parkinson’s Disease

So is it good or bad?! I’ve read some of what you posted but I’m still none the wiser. What do you understand the verdict to be? I’ve been doing the Wim Hof breathing for a few weeks. I can’t say I feel any different!

JayPwP profile image
JayPwP in reply to Dap1948

Wim hof breathing uses both, hyperventilation as well as hypoventilation.

To answer your question, I am confused myself

kaypeeoh profile image
kaypeeoh in reply to Dap1948

I'm familiar with Hof. He uses meditation to inure himself to deep cold.

Just a guess. Exercise is one of the few things known to benefit PD. Exercise requires an elevated heart rate. An elevated heart rate uses oxygen. When leisurely walking the body is using mainly fat for energy. The harder the body is working--by breathing hard--the higher the percentage of sugar being used for energy. Years ago I hired a trainer to help me improve my running. He put me on a stress test treadmill. I wore a mask that captured the CO2 I was expelling. At a leisurely walk my heart rate was 50bpm. I was burning 95% fat. At the other end my heart rate was 185 bpm and I was burning 95% sugar.

I'm sure right now someone is writing the causation/correlation argument. It's known that severe exercise stimulates human growth hormone. Maybe that's a clue.

sharoncrayn profile image
sharoncrayn in reply to kaypeeoh

Continual long term extreme stress, regardless of its origin or type, is not beneficial for slowing the progression of PD. We have discussed this at length before. If it was, individuals such as yourself would not have PD.

Extremely short term hypoxia CTs using rats or humans fail to reach an acceptable level of credibility.


What about hyperbaric oxygen therapy?

I wouldn't say that most breathing techniques involve hypoxia. Deep slow breathing into the belly is a technique that slows heart rate and strengthens the Parasympathetic nervous system (rest and digest). Especially if the exhale is longer than the inhale. Also nasal breathing increases oxygen uptake as well as nitric oxide.

My impression (for myself) is that there is a place for hypoxic exercises, but not if your parasympathetic nervous system is in bad shape (true for a lot of people with PD).

JayPwP profile image
JayPwP in reply to rebtar

If exhaling is longer than inhaling, it is creating an Hypoxia effect.

rebtar profile image
rebtar in reply to JayPwP

Deep breathing, say breathing in for four seconds and out for six, will allow your body to get into a deeply relaxed state. That can only be good, don't you think? It's helped me to be more relaxed, less anxious, improved heart rate variability. How can that be bad for me?

Here's another link on how longer exhalations affect the vagus nerve...

JayPwP profile image
JayPwP in reply to rebtar

I am not questioning the good or bad, I am just saying that depriving the body of Oxygen for a short time is inducing controlled Hypoxia, like wim hof breathing, 3 rounds of 30 breaths of controlled hyperventilation followed by a period of Hypoxia between each round.

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