The Beneficial Role of Thiamine in Parkinson Disease

[Mob0]

pmc.ncbi.nlm.nih.gov/articl...

This is from 2013, but still relevant. Jumping straight to conclusions it provides reasons why B1 is not easily absorbed orally...

...However, gastrointestinal dysfunction is common in patients with PD, and it potentially affects the therapeutic intervention 140. Gastric emptying has been reported to be frequently delayed in patients with PD 141. Decreased nonmediated uptake across the enterocyte brush border membrane was demonstrated in patients with PD 142. In addition, the intestinal absorption of thiamine is sufficient in young people but may be reduced with age 143. Parental administration of thiamine may be suitable for patients with PD 14....

Parental=injectable.

Anyone is aware of a dairy free sublingual version?

[popo1]

sub-lingual, no. but my understanding is that benfothiamine and ttfd (just google it) both cross the bbbarrier well.

i have been doing the b1 protocol, benfothiamine 1.8g/day, for a month now and feel it has helped.

anyone know the dosing difference for ttfd? i believe ttfd is about 4 times less than benfothiamine?

[Bracondale in reply to popo1]

It's confusing as I've read that 'A major difference between the derivatives is that TTFD crosses the blood–brain barrier, whereas Benfotiamine does not' (Lonsdale and Marrs) and another paper (Bosic and Lavrnja) stating that 'Benfotiamine is a promising therapeutic agent for improving cognitive function and protecting against inflammation and oxidative stress-induced cell death in the CNS 'which would imply that it is crossing the BBB. I guess that the proof of the pudding is in the eating!

[Bracondale]

Parental is a typo in the article and should be 'parenteral'!

I looked into sublingual B1 preparations for myself recently and found the following.

'EZ Melts B1' (thiamine mononitrate 25mg) and 'BariMelts B1' (thiamine hydrochloride 12.5mg) both look to be dairy free, whereas 'Superior Source Microlingual B1' (thiamine mononitrate 100mg) states 'contains milk'. If there are conversion (to active pyrophosphate/coenzymated form) as well as absorption issues then 'Source Naturals Coenzymated B1' (13mg) looks to be dairy free.