accutane / isotretonoin : My first... - Cure Parkinson's

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accutane / isotretonoin

Xauxatz profile image
19 Replies

My first Parkinson’s symptoms started just 2 weeks after beginning a treatment for rosacea with accutane / isotretonoin. Isotretonoin has a long list of serious side effects of which I was not aware. It also gave me back pain.

Anyone else here who took accutane and later developed PD?

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Xauxatz profile image
Xauxatz
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19 Replies

When I was sixteen, I took Accutane for acne. That was a long time ago and it was common to take accutane back then.

I know other teens who took Accutane and never got PD.

Bolt_Upright profile image
Bolt_Upright

Isotretinoin: The truth about side effects aad.org/public/diseases/acn...

Bolt_Upright profile image
Bolt_Upright in reply toBolt_Upright

Isotretinoin, also known as Roaccutane, can increase dopamine production in the brain, which may lead to adverse mood effects. Isotretinoin may also influence cognition in adulthood.

The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne 2014 pmc.ncbi.nlm.nih.gov/articl....

Several studies have explained the effect of retinoic acid on serotonin and dopamine secretion and production on molecular levels. They have shown that isotretinoin causes elevation in dopamine production in brain leading to its adverse mood effects; its effect on hippocampus has also been established.

Bolt_Upright profile image
Bolt_Upright in reply toBolt_Upright

Interesting all the gastrointestinal side effects, considering the potential gut brain connection for PD: en.wikipedia.org/wiki/Isotr...

Colitis

Ileitis

Dry throat

Gastrointestinal haemorrhage

Haemorrhagic diarrhoea

Inflammatory bowel disease

Nausea

Pancreatitis

posthinking01 profile image
posthinking01 in reply toBolt_Upright

Hi if Accutane increases dopamine I thought PD was a dopamine deficiency condition?

MarionP profile image
MarionP in reply toposthinking01

You are correct, dopamine deficiency is the root of parkinson's. But excess dopamine can also cause problems, although they are not Parkinson's unless you are taking a dopamine agonist or medication containing dopamine or L-Dopa or Carbidopa, for Parkinson's or a psychiatric condition and it consequently bumps your dopamine too high, there can be side effects which you can certainly look up easily enough. You have heard of Goldilocks no doubt? Too much OR too little of something often causes problems, such as with hypothyroidism versus hyperthyroidism... But too much dopamine as a side effect of something you ingest is not a disease, it is a side effect.

posthinking01 profile image
posthinking01 in reply toMarionP

Brilliant explanation thank you - understand !

YOParky profile image
YOParky

I had really bad rosacea prior to my diagnosis of PD. I don't recall taking any medicine for it though. Rosacea went away sure the after I started treatment for PD

posthinking01 profile image
posthinking01 in reply toYOParky

What treatment did you get that did this ?

YOParky profile image
YOParky in reply toposthinking01

C/L

LAJ12345 profile image
LAJ12345

hubby had acne and roseacea for years then was put on doxycycline for years. Berberine and allimed (garlic) got rid of it alternating with probiotics.

we changed lifestyle ie diet , exercise too.

MarionP profile image
MarionP

No connection. I ate carrots once and later got PD. Just about the same probability of a connection between them as in your example.

posthinking01 profile image
posthinking01 in reply toMarionP

Not really as Accutane is a drug and drugs can harm the body !

SilentEchoes profile image
SilentEchoes

Vitamin A toxicity. This is a temporal relationship and you should report the adverse event to the CDC.

Liver enzymes are monitored while taking isotretinoin. Biologically, Vitamin A is stored in the liver and we have about 2 years supply. No one tests Vit. A levels before beginning treatment with isotretinoin. This is a failure of the medical system.

The serious adverse affects of measles is due to Vit. A deficiency and the treatment is high dose supplementation. No one tests Vit. A levels before immunization. This is a failure of the medical system.

My personal experience is with a documented pesticide poisoning from agricultural misuse by my neighbor. You can imagine the liability of this and the vigorous attempts from the medical and legal cartels to silence me. One of the effects of my poisoning was Vitamin A dumping from the liver. It was my body's attempt to save my life. I now have liver disease and kidney disease (lost one in June). My husband is being evaluated for ALS and has recently developed a DVT. Our youngest son (20) has kidney disease. I am devastated and mad as hell.

Our neighbors wanted our land so badly they were willing to murder us. The medical system didn't give a fuck about consequences for withholding medical diagnosis and treatment. My medmal is well developed and they're afraid of me now. A multiple myeloma diagnosis is immanent for me. My heart is broken for the probably that my son and husband will also be diagnosed with blood cancer. Our older son is at risk of losing his family, how do I prepare him for this?

Question everything.

🕊️ SE

marthasquest profile image
marthasquest

pubmed.ncbi.nlm.nih.gov/357...

Accurate depletes copper and increases oxidative stress which is a key factor in Parkinson’s. It affects ATP7b which is critical for mitochondrial energy production.

marthasquest profile image
marthasquest in reply tomarthasquest

Accutane not accurate

elizajohn1 profile image
elizajohn1

My husband took Accutane as a teenager. diagnosed at age 51 with Parkinson's. His twin brother did not take Accutane and does not have Parkinson's.

inky_t profile image
inky_t

I took Accutane in my late 20s and was diagnosed with Parkinson's at age 49, in retrospect I can trace very early symptoms back to my early 40s.

jacksmar profile image
jacksmar

Interesting. I had terrible acne when I was a teen into my early 20’s and took Accutane forever. And that awful sulfur medication; I smelled like a matchstick. My skin is heavily pock marked. I moved to Florida and the pure air filled sun light and fresh saltwater dried it up quick. I never connected this scenario.

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