Eat Real Food and Protect Your Microbiome

[Bolt_Upright]

I don't have the answers, but the questions are worth looking at. My High School education tells me that PD might start in the gut. This makes sense to me. Therefore, gut inflammation is probably bad, and probably leads to intestinal permeability (leaky gut). And the gut bone is connected to the brain bone. I will shut up now.

Daily Mail: I'm a doctor - these 'healthy' foods may be fueling a colon cancer crisis in young people - dailymail.co.uk/health/arti...

"Gastroenterologist at the University of Miami Dr Maria Abreu, who was recently awarded a grant to study this phenomenon, believes part of the problem is the amount of emulsifiers in modern foods, including those that are in healthy products, such as low-fat yogurts, light salad dressings and peanut butter.

The common additives that help give dairy-free and low and non-fat foods their combined and creamy texture, but have been linked to gut inflammation and disruption of the gut microbiome - the collection of healthy bacteria in the body's digestive tract."

"Under normal conditions, the gut microbiome protects the digestive tract from pathogens and infections and helps prevent and reduce gut inflammation.

When the microbiome is thrown off by medications or certain foods with additives - or the digestive tract is damaged by inflammation - it may increase the risk of cancer.

Dr Abreu told WSVN 7 News: 'Something in the microbiome has changed, and it’s setting in motion this chronic inflammation in the [gastrointestinal] tract.

'These ultra-processed foods create a lot of noise in the microbial system."

[Boscoejean]

"Collectively, there is compelling evidence that the majority of NSAIDs can cause marked shifts in the intestinal microbiota in both animals and humans. However, there are some agents which appear to have no or only minor effect on intestinal bacteria"

" It is now widely recognized that NSAIDs cause shifts in the gut microbiota that favor the development of enteropathy. Gram-negative bacteria, which are typically increased after NSAID treatment, can aggravate the intestinal damage caused by these drugs."

sciencedirect.com/science/a....

[Parkie1 in reply to Boscoejean]

From the age of 18, I regularly took co- codamol for migraine. Age 36, I began to have digestion issues. Endoscopy, and colonoscopy resulted in diagnosis of IBS since nothing showed up. Weaned off the NSAIDS and onto sumatriptan for migraine in my 40's, but my gut continued to get more sluggish. Gradually more of what I now realise as PD symptoms were developing, till I was diagnosed aged 61. I strongly feel that my PD began in my gut, and since it's now understood that brain chemicals are produced there, I wonder how much the NSAIDS have contributed to it .

[Boscoejean in reply to Parkie1]

"Yes, long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can damage the lining of the digestive tract, allowing toxins and bacteria to enter the body. This can lead to a number of complications, including:

Leaky gut

NSAIDs can impair the protective mucous lining of the digestive tract, which can lead to increased intestinal permeability. This allows harmful bacteria and toxins to enter the digestive tract"

gastrojournal.org/article/S....

[Despe in reply to Boscoejean]

Use White Willow Bark instead of NSAIDs.

[Antig]

I agree this is certainly an area to be considered and taken seriously!

[Nicopwp]

eventbrite.co.uk/e/the-impo...

[Bolt_Upright]

There is some evidence that the SCD can normalize your microbiome if you still have all the needed bacteria: The Specific Carbohydrate Diet (SCD): The SCD has been shown to normalize the microbiome in people with Crohn's ncbi.nlm.nih.gov/labs/pmc/a... and UC. ncbi.nlm.nih.gov/labs/pmc/a...