"The two-year program is designed to boost therapies' clinical development"
"The project of Gary W. Miller, PhD, a professor at Columbia University, will assess how to prevent further damage of dopamine-producing neurons by levodopa and its derivatives. Levodopa is the precursor of dopamine and a gold standard therapy for Parkinson’s that effectively reduces early motor symptoms. Evidence suggests the therapy may further damage dopamine-producing neurons due to the overproduction of damaging reactive oxygen species, however."
"Evidence suggests the therapy (levodopa) may further damage dopamine-producing neurons due to the overproduction of damaging reactive oxygen species, however." Be nice to see the evidence.
I've not seen anything conclusive either way. I've read: Evidence for levodopa toxicity comes mainly from in vitro studies which have demonstrated that levodopa can damage dopaminergic neurons by a mechanism that probably involves oxidative stress.
But not seen any in vivo human studies either way. I guess it'd be difficult to measure, in a humans head.
This was just a paragraph from the article about the people who were going to get grants for research so it seems like it was not that in depth which was why I was looking for more research
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APDA Citation: What is wrong with these 2 sentences? Anyone?
