LRRK2 gene and Adenosylcobalamin B12

[mledovich]

For those of us with LRRK@2 genetic variants, it seems that a specific form of b12 (Adenosylcobalamin) helps to reduce the negative effects of the LRRK2 kinase protein:

"The team first studied LRRK2 in cultured cells and brain tissue and found that AdoCbl inhibited LRRK2 in the low micromolar range. They then genetically modified fruit flies and C. elegans worms—organisms that show neurological symptoms roughly analogous to human PD—to express the LRRK2 mutation and found that feeding them AdoCbl slowed the decline in dopamine activity in their brains, demonstrating that treatment with AdoCbl was able to reduce these deficits in a dose-dependent manner. Furthermore, they found that AdoCbl corrected abnormal dopamine transmission in cultured tissues from mouse models with the LRRK2 mutation."

mountsinai.org/about/newsro...

[Missy0202]

I am LRRK2 and have been taking Adenosylcobalamin by seeking health since being diagnosed in 2019 ca.iherb.com/pr/seeking-hea...

[mledovich in reply to Missy0202]

That's the exact one I take too. It's interesting to note that Adenosyl is the form of B12 that is utilized by our mitochondria to produce energy for the citric acid cycle. In addition, later in the day I also take Hydroxycobalamin, a storage form of B12 that the body readily converts to Adenosyl or Methylcobalamin as needed.