Urolithin A (UA) – To anybody taking, what’s your experience?

[Gcf51]

Sometimes, I feel gullible for the fleeing by an over-priced, over-hyped supplement. As I understand, UA is produced by bacteria in your gut and without the right bacteria, your gut can’t produce from food. And, maybe the product is more concentrated than what’s produced by bacteria.

AI Says:

“Urolithin A (UA) is a natural metabolite that may help protect against Parkinson's disease. It's produced from polyphenolics in foods like berries, nuts, and pomegranates. UA has been shown to protect against Parkinson's disease, cerebral hemorrhage, and Alzheimer's disease. It also promotes mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway, which may protect dopaminergic neurons in experimental models of Parkinson's disease. (a)

UA may also promote mitophagy and suppress NLRP3 inflammasome activation in MPTP-induced Parkinson's disease model and lipopolysaccharide-induced BV2 microglial cells. One study found that UA-fed mice showed slight improvements in novel object recognition. (b)

Mitochondrial dysfunction contributes to the development of neurodegenerative diseases like Parkinson's disease, so therapeutic strategies that target mitochondrial dysfunction may have promise in treating PD. (c)

UA has also been shown to reverse the aging process in the immune and hematopoietic systems by encouraging mitochondrial recycling. (d)

This is for informational purposes only. For medical advice or diagnosis, consult a professional.”

(a1)pubmed.ncbi.nlm.nih.gov/349...

(a2)journals.lww.com/nrronline/...

(b1) academic.oup.com/innovateag...

(b2)sciencedirect.com/science/a...

(c)pubs.rsc.org/en/content/art...

(d) eurekalert.org/news-release...

[Gcf51]

 Bolt_Upright from a previous post of yours. "So maybe if I keep taking my PEA, and drink some pomegranate juice, I won't have to pay for that super expensive Mitopure!" How has that approach worked for you.

Reference healthunlocked.com/cure-par...

[Bolt_Upright in reply to Gcf51]

I never started the pomegranate juice but I kept up the 600 mg Palmitoylethanolamide with Luteolin before bed. I have never been diagnosed with PD. I have RBD and I had some other symptoms. I'm feeling really good. RBD is mild now. I hardly ever twitch or jerk. No more face dandruff and I don't get dizzy when I stand from sitting. Who knows if I am really better.

I do a lot of things: rbd-pd-protocols.blogspot.c... (and I need to add daily massage pad massages and smell training twice a day to the list).

[Gcf51 in reply to Bolt_Upright]

I am only taking 315mg PEA and 15mg Luteolin.

Do you fill any different with the PEA and Luteolin? Maybe I should up my dose.

[Bolt_Upright in reply to Gcf51]

I use 600 mg based on this 2017 study: Ultra-micronized Palmitoylethanolamide: An Efficacious Adjuvant Therapy for Parkinson's Disease pubmed.ncbi.nlm.nih.gov/283...

" Abstract

Background: Parkinson's disease (PD) is the subject of intense efforts to develop strategies that slow down or stop disease progression and disability. Substantial evidence points to a prominent role for neuroinflammation in the underlying dopaminergic cell death. Ultramicronized palmitoylethanolamide (um-PEA) is well-known for its ability to promote the resolution of neuroinflammation and exert neuroprotection. This study was designed to assess the efficacy of um-PEA as adjuvant therapy in patients with advanced PD.

Method: Thirty PD patients receiving levodopa were included in the study. The revised- Movement Disorder Society/Unified Parkinson's Disease Rating Scale (MDS-UPDRS) questionnaire was used to assess motor and non-motor symptoms. Clinical assessments were carried out before and after addition of um-PEA (600 mg). MDS-UPDRS questionnaire total score for parts I, II, III, and IV was analyzed using the Generalized Linear Mixed Model, followed by the Wilcoxon signed-rank test to evaluate the difference of each item's mean score between baseline and end of um-PEA treatment.

Results: Addition of um-PEA to PD patients receiving levodopa therapy elicited a significant and progressive reduction in the total MDS-UPDRS score (parts I, II, III and IV). For each item, the mean score difference between baseline and end of um-PEA treatment showed a significant reduction in most nonmotor and motor symptoms. The number of patients with symptoms at basal was reduced after one year of um-PEA treatment. None of the participants reported side effects attributable to the addition of um-PEA.

Conclusion: um-PEA slowed down disease progression and disability in PD patients, suggesting that um-PEA may be an efficacious adjuvant therapy for PD."

[Gcf51]

Chances are, I would need much more than the 1.5L of PJ as stated by the study. I think I might bite the bullet and order some. It would make me feel better about this, if someone on HU would provide some positive results.

Study linked by  Bolt_Upright nature.com/articles/s41430-...

“Based on the findings of the current study, to achieve the equivalent dosing of 500 mg supplementation of UA from dietary exposure via PJ, on average, an individual would need to drink six glasses (approx.1.5L) of PJ that contained the necessary dietary precursors.”