Glioblastoma and Parkinson's; hereditary?

[Jmellano]

My mom was diagnosed with gliblastoma (brain cancer) in 2000. I was diagnosed with PD in 2015, If I understand it correctly, the folloing article indicates both conditions apparently can involve the same set of genes.

ncbi.nlm.nih.gov/pmc/articl...

I am wondering if I might have inherited PD because my Mom had glioblastoma? Has anyone else had a connection like that?

Although I dont know how much before she was diagnosed with brain cancer that my Mom started to exhibit a puzzling fleeting symptom that has affected me only recently. I cannot figure out to do things or comprehend instruction manuals; things I never gave a second thought to, like folding the laundry rack. My mom stuggled to read the instruction manual and apply what she read to program the VCR. I can feel her frustration now.

[Jmellano]

I found another article that speaks to PD, bliblastoma and genetics;

mskcc.org/news/researchers-...

[Boscoejean]

"A study led by The Hospital for Sick Children (SickKids) explores new links between glioblastoma and dopamine, a chemical signal of the brain’s reward system. Brain scientists have long understood that when the brain does not have sufficient amounts of dopamine, or if dopamine signalling is interrupted, the severe neurodegenerative condition known as Parkinson’s disease will occur. In the new study, the team identified chemicals that block dopamine function in glioblastoma tumours in the lab, essentially making glioblastoma stem cells (the cells that drive tumour formation) undergo a rapid neurodegenerative process. But instead of causing Parkinson’s, this process degraded or killed the glioblastoma stem cells. The paper is published in the June 13 online edition of Cancer Cell."

sickkids.ca/en/news/archive...

[Jmellano in reply to Boscoejean]

Thank you Boscoejean . I saw this. The connection between glioblastoma and Pd is interesting, although it cannot not help me with PD nor could it have helped my mom.

[buzbyc]

Thanks for posting this, I had never been aware of this possible connection. Yes, my Mum died in 2005 of a glioblastoma and I was diagnosed with PD in 2014.

Without going through the paper line by line am I right in thinking that there is the potential for someone with the identified genetic mutation to develop either PD or glioblastoma?

Nick

[Jmellano in reply to buzbyc]

buzbyc I am not qualified to agree or disagree with the article, but I do find the connection that is identified between glioblastoma and pd quite interesting

[JayPwP]

Glioblastoma recovery

youtu.be/FEA6BQARqE8(Not working as expected?)

youtu.be/jhE-JD6SZWM(Not working as expected?)

[Gigi_12]

My father died of a glioblastona 15 years ago and I was diagnosed 3 years ago with Parkinsons. No other history of PD in my family.

[Jmellano in reply to Gigi_12]

i have no histoty of PD in my family nor was i exposed to pesticides that I aware of,.

[Chicoman]

Jmellao,

I was diagnosed in the summer of 2024 with PD. My brother died of a Glioblastoma in 2009. My mother died from Alzheimer’s. Gee , ya think there might be a connection?

[Jmellano in reply to Chicoman]

Interesting, that may have been a contributing factor in my PD occurrence. I do believe my zd ws triggered (emotional traumaby the suicide of my life partner