Just wondering whether to reorder my sacc. boulardii which I bought originally to combat candida, and on googling saw it's also relevant to PD - thought I'd share for those who missed this July study:
pubmed.ncbi.nlm.nih.gov/367...
'Mitochondrial impairment is a hallmark feature of neurodegenerative disorders, such as Parkinson disease, and PRKN/parkin-mediated mitophagy serves to remove unhealthy mitochondria from cells. Notably, probiotics are used to alleviate several symptoms of Parkinson disease including impaired locomotion and neurodegeneration in preclinical studies and constipation in clinical trials. There is some evidence to suggest that probiotics can modulate mitochondrial quality control pathways. In this study, we screened 49 probiotic strains and tested distinct stages of mitophagy to determine whether probiotic treatment could upregulate mitophagy in cells undergoing mitochondrial stress. We found two probiotics, Saccharomyces boulardii and Lactococcus lactis, that upregulated mitochondrial PRKN recruitment, phospho-ubiquitination, and MFN degradation in our cellular assays. Administration of these strains to Drosophila that were exposed to paraquat, a mitochondrial toxin, resulted in improved longevity and motor function. Further, we directly observed increased lysosomal degradation of dysfunctional mitochondria in the treated Drosophila brains. These effects were replicated in vitro and in vivo with supra-physiological concentrations of exogenous soluble factors that are released by probiotics in cultures grown under laboratory conditions.' (extract from Abstract)
Great video on healing a "leaky gut" and I found this probiotic to be the best deal on Amazon!
Has anyone heard about K2 a Vitamin. I hope it's true and not another Scam
Probiotic, Solace PS128, Eases ‘Off’ Periods, Motor Symptoms in Trial (PRWEB) NOVEMBER 08, 2021
Prebiotic Probiotic Antibiotic... What's the deal?
Hands up all those who have heard of a protein called LC3B?
