Anyone heard of or tried cGPmax?

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en.wikipedia.org/wiki/Cycli...

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“Insulin-like growth factor-1 (IGF-1) function declines with age and is associated with brain ageing and the progression of age-related neurological conditions. The reversible binding of IGF-1 to IGF binding protein (IGFBP)-3 regulates the amount of bioavailable, functional IGF-1 in circulation. Cyclic glycine-proline (cGP), a metabolite from the binding site of IGF-1, retains its affinity for IGFBP-3 and competes against IGF-1 for IGFBP-3 binding. Thus, cGP and IGFBP-3 collectively regulate the bioavailability of IGF-1. The molar ratio of cGP/IGF-1 represents the amount of bioavailable and functional IGF-1 in circulation. The cGP/IGF-1 molar ratio is low in patients with age-related conditions, including hypertension, stroke, and neurological disorders with cognitive impairment. Stroke patients with a higher cGP/IGF-1 molar ratio have more favourable clinical outcomes. The elderly with more cGP have better memory retention. An increase in the cGP/IGF-1 molar ratio with age is associated with normal cognition, whereas a decrease in this ratio with age is associated with dementia in Parkinson disease. In addition, cGP administration reduces systolic blood pressure, improves memory, and aids in stroke recovery. These clinical and experimental observations demonstrate the role of cGP in regulating IGF-1 function and its potential clinical applications in age-related brain diseases as a plasma biomarker for—and an intervention to improve—IGF-1 function.”

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5. Discovery of Natural cGP

New Zealand blackcurrants contain natural cGP [45]. In an open-label trial conducted in 13 PD patients with normal cognitive function, supplementation with the capsulised blackcurrant extract (BCA) resulted in a significant increase in cGP concentration in the cerebrospinal fluid (CSF) of the participants, without altering CSF concentration of IGF-1 and IGFBPs. The concentration of cGP in the CSF is correlated with plasma cGP concentration. These data suggest that BCA capsules provide natural cGP, which is orally bioavailable to the human brain. While there is no improvement in motor function, the Hospital Anxiety and Depression Scale (HADS) and subscale anxiety scores of the participants are reduced after 4 weeks of supplementation [111] (Table 2). It is surmised that these effects are mediated by cGP, since the supplementation increases the concentration of cGP in the plasma and CSF of the PD patients [45].”