I did not understand all of this, but I am going to keep taking my 400 mg of Swanson Magnolia Extract every night. Been taking it for well over a year.
Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint 2023 cmjournal.biomedcentral.com...
"Concluding remarks and future directions
Even while technological advances have significantly sped up the process of assessing phytochemicals, there is still a lot of work to be done until we have a more definite understanding of the neurotherapeutic advantages of herbal medications. As a consequence of our findings and other studies' findings, we have concluded that honokiol's ability to change several signaling pathways makes it potentially useful as a medicine for treating NDs. Despite the limitations of the ongoing clinical study, honokiol is showing great potential as a potential treatment for a wide range of NDs, including AD, PD, cerebral ischemia, anxiety, depression, spinal cord, and others. Even though a significant amount of preclinical research studies have been carried out to evaluate the neurotherapeutic potential of honokiol, the compound's clinical potential has not yet been used. There is a need for more research to improve the bioavailability of honokiol and for clinical studies to be carried out to evaluate the therapeutic efficacy of these compounds."
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Neuroinflammation is a complex process that plays a role in various complex conditions affecting the brain, including ischemia injury and neurodegenerative diseases such as multiple sclerosis and PD [49]. Atrophy of projection fibers from the substantia nigra pars compacta to the striatum results from the progressive death of substantia nigra pars compacta dopaminergic (DA) neurons, the most frequent movement state in adults. Activation of glial cells, such as astrocytes and microglia, is a pivotal biological process in neuroinflammation. Astrocytes and microglia undergo substantial structural changes during inflammation, followed by increased production of essential immunomodulatory cytokines [50, 51]. Consequently, astrocytes and microglia, under conditions of inflammatory stress, can produce several cytokines that promote inflammation. These cytokines include IL-6, TNF-α, and IL-1β [52]. Other transcription factors, such as the well-known regulator NF-kB and Krüppel-like factor 4 (KLF4), are involved in similar regulatory pathways that regulate the expression of pro and anti-inflammatory cytokines. Indeed, in addition to its actions in maintaining stem cells, KLF4 was associated with the overexpression of IL-10 and iNOS in macrophages and IL-6 in dendritic cells [53]. Endothelial cells and microglia-like cells belonging to the immune system may benefit from the role that KLF4 plays in regulating pro-inflammatory mediators [54].
Many PPARγ agonists have been shown to provide neuroprotective benefits in both in vitro and in vivo models. Dozens of different animal models of PD have revealed that PPARγ activation reduces levels of OS and inflammation, improves mitochondrial function, reduces glial activation, slows the rate of nigral dopaminergic neuron loss, and increases striatal dopamine levels (Fig. 5) [55, 56]. These outcomes conclude that PPARγ may be a therapeutically productive target for treating PD. So, therapeutic interventions targeting PPARγ in people with PD may effectively reduce the severity of disease symptoms and halt the long process of neurodegeneration [57, 58]…”
Vitamin b3 na does the same thing:
“So, therapeutic interventions targeting PPARγ in people with PD may effectively reduce the severity of disease symptoms and halt the long process of neurodegeneration”.
I don't know. I have not been diagnosed with PD. I have REM Sleep Behavior Disorder, which doctors say is prodromal PD. When I was diagnosed in April 2021 I also had a sore left shoulder and left leg, face dandruff, get dizzy when I stand, and have random involuntary movements. I can say "had" to most of those conditions: My RBD is now very mild and rare. Random involuntary movements are rare. I don't get dizzy when I stand. My face dandruff gone. My sore shoulder is still sore, but not as bad. I have gone back to using a mouse left handed after a year of going right handed. I should also add: I do a lot of things besides PEA.
I also used to have an occasional tremor in my left hand. Maybe every week or two. Like when I was holding a plate, or washing silverware. And even when it did not tremor, the hand felt like it might tremor (if that makes sense). It was very minor. That seems to be gone (please don't jinx myself, please don't jinx myself, please don't jinx myself).
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This is worth your time to look at ... Benedlife.com says it has clinical proof their supplement (take with your regular PD meds) WORKS!
BioVie announces treatment of 1st patient in Phase 2 clinical trial of NE3107,ERK inhibitor that selectively inhibits neuroinflammation
