New treatment for neurodegenerative diseases may be found in used coffee grounds

[Bolt_Upright]

New treatment for neurodegenerative diseases may be found in used coffee grounds: Caffeic-acid based Carbon Quantum Dots have the potential to be transformative in the treatment of neurodegenerative disorders 2023 caledonianrecord.com/featur...

Kumar and his colleagues found that CACQDs were neuroprotective across test tube experiments, cell lines and other models of Parkinson's disease when the disorder was caused by a pesticide called paraquat. The CACQDs, the team observed, were able to remove free radicals or prevent them from causing damage and inhibited the aggregation of amyloid protein fragments without causing any significant side effects.

The team hypothesizes that in humans, in the very early stage of a condition such as Alzheimer's or Parkinson's, a treatment based on CACQDs can be effective in preventing full-on disease.

"It is critical to address these disorders before they reach the clinical stage," Narayan said. "At that point, it is likely too late. Any current treatments that can address advanced symptoms of neurodegenerative disease are simply beyond the means of most people. Our aim is to come up with a solution that can prevent most cases of these conditions at a cost that is manageable for as many patients as possible."

Caffeic acid belongs to a family of compounds called polyphenols, which are plant-based compounds known for their antioxidant, or free radical-scavenging properties. Caffeic acid is unique because it can penetrate the blood-brain barrier and is thus able to exert its effects upon the cells inside the brain, Narayan said.

The process the team uses to extract CACQDs from used coffee grounds is considered "green chemistry," which means it is environmentally friendly. In their lab, the team "cooks" samples of coffee grounds at 200 degrees for four hours to reorient the caffeic acid's carbon structure and form CACQDs.

[Getz]

Mate there is some great research on coffee cherry as a supplement. I have posted previously but suggest you check it out.

[Bolt_Upright in reply to Getz]

Thanks!

[park_bear]

"neuroprotective across test tube experiments, cell lines and other models of Parkinson's disease when the disorder was caused by a pesticide called paraquat. The CACQDs, the team observed, were able to remove free radicals or prevent them from causing damage [i.e. antioxidant]...in the very early stage of a condition such as Alzheimer's or Parkinson's, a treatment based on CACQDs can be effective in preventing full-on disease.'It is critical to address these disorders before they reach the clinical stage' " [emphases added]

This screams out pre-treatment. Prevents the adverse effects of toxicants as do most antioxidants.

Diagnosis prior to obvious clinical symptoms would be great. Never mind that. How about diagnosis of obvious clinical symptoms? I pointed out my intermittent one-sided resting tremor to a couple of otherwise competent general practitioner MDs years before my actual diagnosis. They had no idea.

[Hidden in reply to park_bear]

Yes I agree - the GP's are the first line and you have to argue and jump up and down with them to clean the fog out of their eyes and ears. It took me over 5 years to get my husbands GP to see and acknowledge the symptoms - by then it was too late for early intervention. I know they have to have a broad knowledge of a lot but the biggest issue I have with them is they don't listen and are too dismissive - the attitude has to change.

[Bolt_Upright]

Thanks Getz

☐ New treatment for neurodegenerative diseases may be found in used coffee grounds: Caffeic-acid based Carbon Quantum Dots have the potential to be transformative in the treatment of neurodegenerative disorders 2023 caledonianrecord.com/featur...

Kumar and his colleagues found that CACQDs were neuroprotective across test tube experiments, cell lines and other models of Parkinson's disease when the disorder was caused by a pesticide called paraquat. The CACQDs, the team observed, were able to remove free radicals or prevent them from causing damage and inhibited the aggregation of amyloid protein fragments without causing any significant side effects.

The team hypothesizes that in humans, in the very early stage of a condition such as Alzheimer's or Parkinson's, a treatment based on CACQDs can be effective in preventing full-on disease.

"It is critical to address these disorders before they reach the clinical stage," Narayan said. "At that point, it is likely too late. Any current treatments that can address advanced symptoms of neurodegenerative disease are simply beyond the means of most people. Our aim is to come up with a solution that can prevent most cases of these conditions at a cost that is manageable for as many patients as possible."

Caffeic acid belongs to a family of compounds called polyphenols, which are plant-based compounds known for their antioxidant, or free radical-scavenging properties. Caffeic acid is unique because it can penetrate the blood-brain barrier and is thus able to exert its effects upon the cells inside the brain, Narayan said.

The process the team uses to extract CACQDs from used coffee grounds is considered "green chemistry," which means it is environmentally friendly. In their lab, the team "cooks" samples of coffee grounds at 200 degrees for four hours to reorient the caffeic acid's carbon structure and form CACQDs.

☐ Neurophysiological Effects of Whole Coffee Cherry Extract in Older Adults with Subjective Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Pilot Study 2021 ncbi.nlm.nih.gov/pmc/articl...

☐ Coffee Fruit report: alzdiscovery.org/uploads/co...

[Reetpetitio in reply to Bolt_Upright]

That looks pretty cool about coffee cherry extract increasing BDNF - do you take it?

[Bolt_Upright in reply to Reetpetitio]

No. I just found this info and added it to my list of things to investigate.

[gomelgo in reply to Bolt_Upright]

I would take cherry extract even if it didn't do anything for my symptoms. Sounds yummy.

[Bolt_Upright in reply to gomelgo]

It's coffee cherry. The outer skin of the coffee bean.

[gomelgo in reply to Bolt_Upright]

Oooooh! K, never mind then, though it might still be tasty, but prolly pretty anxiety producing too.

[Reetpetitio in reply to gomelgo]

I think it's very very low in caffeine.... it's the fruit before the bean develops

Did sound amazing when I read up on it, but I'm at the ten-tabs-open-for-days-no-action stage - and now researching modified citrus pectin!

[gomelgo in reply to Reetpetitio]

Tell us about the pectin!

[Reetpetitio in reply to gomelgo]

alzdiscovery.org/uploads/co...

Also check out Dr Isaac Elias on the Parkinsons Solutions Summit on this! still available for free today.

His pectin product has 20% off for Black Friday:

dreliaz.org/formulas/modifi...

[gomelgo in reply to Reetpetitio]

Thank you. I am feeling pretty overwhelmed ATM. Can I please get a TLDR version?

[Reetpetitio in reply to gomelgo]

It seems to reduce neuro-inflammation, and reduces Galactin-3, which is higher in people with PD and even higher in people with advanced PD (and other stuff that is beyond me to summarise!) basically a Very Good Thing

[gomelgo in reply to Reetpetitio]

Thank you! I have never heard of this galactin-3. How do they test for it?

[Reetpetitio in reply to gomelgo]

sorry I have no idea, but you can click that alzdiscovery link above to learn more

[Sun_and_flowers in reply to Reetpetitio]

My case, but about 100 tabs or more, open! 😬🙄Makes me feel a little better to know I'm not the only one... 😂 (or am I...? Over a hundred may make me the only one... 🤪)

[Getz]

Haven't read this before. My research came up with the coffee cherry as being useful. Not the coffee bean.

[kaypeeoh]

Years ago I saw a article about re-using coffee grounds. The used grounds were cooked in a 300 degree oven for an hour to extract more caffeine.

[Ponieboy]

I literally just read this article this evening. Looks interesting.