New treatment for neurodegenerative diseases may be found in used coffee grounds: Caffeic-acid based Carbon Quantum Dots have the potential to be transformative in the treatment of neurodegenerative disorders 2023 caledonianrecord.com/featur...
Kumar and his colleagues found that CACQDs were neuroprotective across test tube experiments, cell lines and other models of Parkinson's disease when the disorder was caused by a pesticide called paraquat. The CACQDs, the team observed, were able to remove free radicals or prevent them from causing damage and inhibited the aggregation of amyloid protein fragments without causing any significant side effects.
The team hypothesizes that in humans, in the very early stage of a condition such as Alzheimer's or Parkinson's, a treatment based on CACQDs can be effective in preventing full-on disease.
"It is critical to address these disorders before they reach the clinical stage," Narayan said. "At that point, it is likely too late. Any current treatments that can address advanced symptoms of neurodegenerative disease are simply beyond the means of most people. Our aim is to come up with a solution that can prevent most cases of these conditions at a cost that is manageable for as many patients as possible."
Caffeic acid belongs to a family of compounds called polyphenols, which are plant-based compounds known for their antioxidant, or free radical-scavenging properties. Caffeic acid is unique because it can penetrate the blood-brain barrier and is thus able to exert its effects upon the cells inside the brain, Narayan said.
The process the team uses to extract CACQDs from used coffee grounds is considered "green chemistry," which means it is environmentally friendly. In their lab, the team "cooks" samples of coffee grounds at 200 degrees for four hours to reorient the caffeic acid's carbon structure and form CACQDs.
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"neuroprotective across test tube experiments, cell lines and other models of Parkinson's disease when the disorder was caused by a pesticide called paraquat. The CACQDs, the team observed, were able to remove free radicals or prevent them from causing damage [i.e. antioxidant]...in the very early stage of a condition such as Alzheimer's or Parkinson's, a treatment based on CACQDs can be effective in preventing full-on disease.'It is critical to address these disorders before they reach the clinical stage' " [emphases added]
This screams out pre-treatment. Prevents the adverse effects of toxicants as do most antioxidants.
Diagnosis prior to obvious clinical symptoms would be great. Never mind that. How about diagnosis of obvious clinical symptoms? I pointed out my intermittent one-sided resting tremor to a couple of otherwise competent general practitioner MDs years before my actual diagnosis. They had no idea.
Yes I agree - the GP's are the first line and you have to argue and jump up and down with them to clean the fog out of their eyes and ears. It took me over 5 years to get my husbands GP to see and acknowledge the symptoms - by then it was too late for early intervention. I know they have to have a broad knowledge of a lot but the biggest issue I have with them is they don't listen and are too dismissive - the attitude has to change.
☐ New treatment for neurodegenerative diseases may be found in used coffee grounds: Caffeic-acid based Carbon Quantum Dots have the potential to be transformative in the treatment of neurodegenerative disorders 2023caledonianrecord.com/featur...
Kumar and his colleagues found that CACQDs were neuroprotective across test tube experiments, cell lines and other models of Parkinson's disease when the disorder was caused by a pesticide called paraquat. The CACQDs, the team observed, were able to remove free radicals or prevent them from causing damage and inhibited the aggregation of amyloid protein fragments without causing any significant side effects.
The team hypothesizes that in humans, in the very early stage of a condition such as Alzheimer's or Parkinson's, a treatment based on CACQDs can be effective in preventing full-on disease.
"It is critical to address these disorders before they reach the clinical stage," Narayan said. "At that point, it is likely too late. Any current treatments that can address advanced symptoms of neurodegenerative disease are simply beyond the means of most people. Our aim is to come up with a solution that can prevent most cases of these conditions at a cost that is manageable for as many patients as possible."
Caffeic acid belongs to a family of compounds called polyphenols, which are plant-based compounds known for their antioxidant, or free radical-scavenging properties. Caffeic acid is unique because it can penetrate the blood-brain barrier and is thus able to exert its effects upon the cells inside the brain, Narayan said.
The process the team uses to extract CACQDs from used coffee grounds is considered "green chemistry," which means it is environmentally friendly. In their lab, the team "cooks" samples of coffee grounds at 200 degrees for four hours to reorient the caffeic acid's carbon structure and form CACQDs.
☐ Neurophysiological Effects of Whole Coffee Cherry Extract in Older Adults with Subjective Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Pilot Study 2021ncbi.nlm.nih.gov/pmc/articl...
It seems to reduce neuro-inflammation, and reduces Galactin-3, which is higher in people with PD and even higher in people with advanced PD (and other stuff that is beyond me to summarise!) basically a Very Good Thing
My case, but about 100 tabs or more, open! 😬🙄Makes me feel a little better to know I'm not the only one... 😂 (or am I...? Over a hundred may make me the only one... 🤪)
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