most exciting information possible cure insight!!

[Erniediaz1018]

tiktok.com/t/ZT8DEhvEB/

[Juliegrace]

Care to elaborate for those of us who don’t have/want TikTok?

[park_bear in reply to Juliegrace]

The video is woefully deficient in relevant information. This is apparently the drug being referred to: parkinsonsnewstoday.com/new...

The study underlying this news article is here: sciencedirect.com/science/a...

Refreshingly, the researchers were serious about using a valid Parkinson's model:

"PD manifests over several years and is therefore a progressive disease. In our hands we find that acute intrastriatal bilateral infusion of 6- hydroxydopamine leads to a maximal loss of tyrosine hydro- xylase (TH) neurons and terminals within only 10–12 days (Meshul, unpublished data), which is not a representative time frame for DA loss in PD patients. Therefore, we utilized a mouse model of PD, which consists of injecting MPTP in a graded manner over 4 weeks, to better mimic the develop- ment/progression of this disease. In this current study, mice were injected with MPTP (5 days/week) with increasing dosages each week (10, 20, 24, 32 mg/kg/d). GA injections (3.5 mg/kg: 7 days/week) commenced after the last MPTP injections for 4 weeks to investigate the extent of restoration that would occur during 4 weeks of treatment with this microglial modulating drug."

And the treatment was efficacious: "GA [Glatiramer Acetate / Copaxone] treatment effectively reversed clinical (motor dysfunction) and pathology (TH, IBA1, BDNF expression) of PD in a murine model"

drugs.com/mtm/glatiramer-in... "Glatiramer injections are given either daily or 3 times per week, depending on your dose."

goodrx.com/glatiramer $1836 US for 12 doses.

I can foresee some difficulty persuading a doctor to prescribe this, and even more difficulty persuading a US insurer to pay for it off label. For those using Medicare Part D, the insurance is supposed to pick up the cost when annual expense for medication exceeds about $7000

There is risk associated with this treatment. About 15% of users experience serious allergic reactions: drugs.com/comments/glatiram...

If this were to work in humans I wonder how many doses would be required and what the maintenance dose would be thereafter.

[jimcaster]

I'd like to be excited, but mice don't get Parkinson's Disease. There must be dozens of drugs which "cure" Parkinson's in mouse models, but none of them have produced a cure in human beings.

[MBAnderson in reply to jimcaster]

I'm with you Jim, unless your PD was caused by MTPT.

And the stuff is not without risk, as per Mayo Clinic.

While all lists if side effects appear troublesome, this list seems particularly so. The question is, which of these side effects would you risk adding on to your PD?

A few of the more notable.

"Symptoms of your MS may return and become worse after stopping treatment ...

Avoid being near people who are sick or have infections while you are using this medicine. Wash your hands often.

blindness

difficulty...moving

paralysis

... liver failure ...

coughing up blood

chest pain

joint pain

lower back or side pain

neck pain

nerve pain

ear pain

eye pain

pain ... in arms or jaw

stomach pain

painful... urination

trouble breathing

confusion

difficulty with swallowing

severe and throbbing headache

itching of the vagina or outside genitals

pain during sexual intercourse

purple spots under the skin

red streaks on the skin

shakiness in the legs, arms, hands, or feet

small lumps under the skin

spasm of the throat

strong urge to urinate

swelling of the fingers, arms, feet, or legs

thick, white curd-like vaginal discharge without odor or with mild odor

trembling or shaking of the hands or feet

Blood in the urine

burning or stinging of the skin

continuous, uncontrolled back-and-forth or rolling eye movements

decreased sexual ability

diarrhea

painful cold sores or blisters on the lips, nose, eyes, or genitals

sensation of motion, usually whirling, either of oneself or of one's surroundings

speech problems

vision problems

Abnormal vaginal bleeding or discharge

bleeding gums

blurred or decreased vision

clear or bloody discharge from the nipple

cloudy urine

dark urine

decreased urine output

difficult or frequent urination

dilated neck veins

dimpling of the breast skin

extreme tiredness or weakness

general tiredness and weakness

hair loss

heartburn

increased menstrual flow or vaginal bleeding

inverted nipple

joint swelling

large amount of cholesterol in the blood

lump in the breast or under the arm

lump or swelling in the stomach

muscle weakness, sudden and progressing

nausea

nosebleed

persistent crusting or scaling of the nipple

prolonged bleeding from cuts

puffiness or swelling of the eyelids or around the eyes, lips, or tongue

rapid, shallow breathing

recurrent fever

red or black, tarry stools

redness or swelling of the breast

seizures

sore on the skin of the breast that does not heal

sore throat

stiff neck or back

tearing

tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area

unusual tiredness or weakness

upper right abdominal or stomach pain

vomiting

yellow eyes or skin

mayoclinic.org/drugs-supple...

[Boscoejean in reply to MBAnderson]

Lists like this make you leary of medication treatment and in my mind a very good reason to have some skepticism when you see a long list of really bad side effects like this

This makes those interventions like gloves,healthy diet, red light therapy, exercise, meditation, and phototherapy seem much more inviting to pursue

When we are at home watching tv and they put on an ad for a new drug and then at the end they list every bad thing that can happen to the person my husband and I would say something like, oh yeah sure like we want to invite that. I mean you sometimes have to laugh but then you think of all the people who might suffer these horrible outcomes because they don't listen to this part of the ad and I can understand WHY the hope of eliminating so many troubling symptoms would seem miraculous but may not quite turn out that way.

[MBAnderson in reply to Boscoejean]

So true.

I put up that list because it is worse than many others.

I don't know if I would risk getting one of those against the odds of being in the cohort where the drug did little or nothing.

About 20 years ago, I saw an ad on TV that listed as one of the side effects, "which occurred in a majority of people" as "uncontrolled, explosive diarrhea." Ha. You got to be seriously ill to take such a drug.

[Erniediaz1018 in reply to MBAnderson]

🤣🤣🤣

[gomelgo in reply to Boscoejean]

My all time favorite example of this was when viagra first came out and the top possible side effect listed was "sexual dysfunction"! Human hubris is not working and yet, we seem to be doubling down on the belief that we will outsmart our own self created diseases and disasters. We shit on our home, and then try to pretend like we didn't know that would cause issues .... oy don't get me started. I believe we are part of nature, and we need an extra large dose of nature to humble us back home to ourselves. Just my personal take on the current circus.

[Erniediaz1018 in reply to MBAnderson]

wow

[Erniediaz1018 in reply to jimcaster]

Thank you Jim

[WinnieThePoo in reply to jimcaster]

yet

[Erniediaz1018]

thank you all for sharing your personal experiential knowledge 🤗

[crewmanwhite]

Another "cure" that does nothing about the causes, so will only cause more long-term problems, but make lots of money.

[LeharLover62]

Interesting find! I notice that the mouse study parkbear found was from 2019 so why not more hype on this drug?

Also, as it’s an MS treatment it is an immunomodulating drug. Makes me more convinced there could be immune issues implicated in PD.

Ooo…. And I found this in a different article:

Indeed, cognitive functions were found to be either preserved, reversed, or improved after the less frequent treatment regimens with GA in animal models of AD.

[MarionP]

Well it is used to suppress autoimmune attack of the myelin that insulates nerve cells, i.e. MS (multiple sclerosis) and there are now two forms, daily injection or the longer version which is three injections per week.

Because it interrupts your immune system, those side effects are likely all about things that happen when one or more immune system cytokines are stopped (various interleukins), and this medication stops inflammatory T cells that trigger interleukins to "flame on" (attack the myelin surrounding your nerve cell), which in turn stops several interleukins, and in fact also turns on a different T cell that tells your system to kill those interleukins. So without those interleukins, something (several somethings actually) in your immune system is turned off and missing. No further information on that except the names of the actual interleukins suppressed, looks like about six of them.

So it might be that immune system functions involving those cytokines in other parts of the body are affected or defeated, leading to those side effects as those immune responses that serve various system functions are now defeated during the time that the injection is effective.

The drug itself is composed of four amino acids found in myelin, in repetion sizes of various random numbers, cells of different size linked together, like the way plastics are, set sequence of atoms that are then repeated over and over and over and chain together to make longer molecules, like thread, but the sizes of the indivual molecules vary in the number of aroms the molecules are composed of, so they are termed "random polymers" of those basic four atom sets, and so I imagine those amino acids react with things found all throughout the body and so this med somehow interacts with things all around your system, but the actual mechanism is supposed to be not fully known so there's not much really specific can be said about its effects, except all those side effects that have been listed have been observed and obviously it's a very very big list.

So with all this gobbledygook it leaves one with no idea about it really.

[MBAnderson]

"... all those side effects ... have been observed..."

Pretty bad.

[Ramuu]

Hi Erniediaz 1018 , This link won't open , please advise

[bassofspades]

Wow those lucky mice, catching all the breaks!

Maybe, just maybe...if we think mouse thoughts...eat cheese.... perhaps a mouse to human fecal transplant to mimic the mouse gut microbiome..,.then maybe it just might work!

Squeak, I say! Squeak!

[bassofspades in reply to bassofspades]

Seriously though, that could be exciting if it goes where it needs to get to.