Cure

President Obama Put Joe Biden in Charge of Curing Cancer. Let us ask Joe Biden to cure Parkinson’s

[gaga1958]

Were there any cures for cancer developed?

[lilibelle in reply to gaga1958]

He's not accomplished anything before - don't expect him to now.

[pdpatient in reply to lilibelle]

And you have what evidence, lilibelle? Compared to the moron who sulks in the white house, Biden is an Angel.

[Farooqji]

Let's hope

[MarionP in reply to Farooqji]

Hope. Now there's a plan.

[Patrickk]

Bydureon, a repurposed Type 2 Diabetes drug is now in third-stage trials in UK for stopping Parkinson’s in its tracks — results expected 2023. Testing — mice, open label, double blind — has been going on for 10 years and it has been positive every time.

scienceofparkinsons.com/201...

According to a very sensitive test, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), 2/3 of Parkinson’s patients are supposed to be insulin resistant. IR may be treated with Bydureon (Exanatide). Just an angle that might get us one step closer to Bydureon.

scienceofparkinsons.com/201...

cureparkinsons.org.uk/news/...

[pdpatient in reply to Patrickk]

I hate to break it to you, Patrickk, but after several years on Bydureon and Trulicity, I have not seen any positive results that last.

[Hidden in reply to pdpatient]

One wouldnt expect you to "see" positive results. At issue is whether once weekly 2mg subcutaneous injection slows progression as compared a placebo.

[pdpatient in reply to Hidden]

ChrisWF, read my other post. You will find it interesting.

[Patrickk in reply to pdpatient]

Pdpatient, could you narrow down a little bit on what you mean by "positive results." Does that mean improvement in symptoms or not slowing or stopping progression? The latter is what I've seen reported -- in just about every (or maybe every) subject who got the real drug (not the placebo).

[pdpatient in reply to Patrickk]

EDITED:

Patrickk, I don't know how to measure progression or the lack thereof. My MDS never tells me. My UPDRS score fluctuates between 20 and 28 during most visits. On a rare occasion I have seen a score of 49. I will ask the doctor next time if he thinks that I have progressed. However, I never got his buy-in on this possibility of Exenatide treatment though. I got it prescribed for me because I am diabetic. I am off of it now because I had less effective Levodopa absorption due to slow gastric emptying triggered by the Exenatide. However for the reasons I state below, I too am skeptical about it's prospects. I am not a conspiracy theorist, but based on my experience, I think that drug repurposing is just another attempt to expand the universe of gullible patients/customers.

Here's a very interesting bit of information that might spike your curiosity further. I was an early adopter of Exenatide because it was touted as a effective treatment of diabetes. It was called Byetta and injected 3 times a day before meals. That was probably 2006 or 2007. I developed Parkinson's in 2012 (initial diagnosis by local neurologist). I had a very bad right thumb tremor at that time, which is what I still have today.

Come to think that it I should have not developed Parkinson's early at the age of 48. Or, maybe someone might say that it perhaps delayed my diagnosis. Hard to say. The only thing that I know is that coming from a very large extended family of hundreds the relatives, I am the only one with the disease. Luck of the draw in life sucks.

Of course the meds I take, including Rytary, Nourianz, Ropinrole and Amantadine gives me biphasic dyskinesia. Perhaps the fact that I still have just the right thumb tremor means no progression? I can't tell the difference anymore because of the terrible dyskinesia which results in strong tremors at both ON ramps as well as OFF ramps.

[Astra7 in reply to pdpatient]

Are you diabetic or trialling these for PD?

[pdpatient in reply to Astra7]

Astra7, I am diabetic. If you read my post below, I have been injecting Exenatide ever since it came out and prior to my Parkinson's diagnosis.

[MarionP in reply to pdpatient]

Positive depends on "compared to what?" The definition is not always what the speaker intends unless clarified right there. In clinical terms, "positive" results can mean that the treatment made some improvement from the current status OR TREND before it's sole intervention, from wherever that particular target was at the time of introduction, and caused by that treatment. It matters to define your terms.

Context meant vs. context perceived also matters. Sliding slower down a mountain than prior to introduction may just count as a positive result. But assumption on both sides is often just an individual, hidden speculation, the responsibility of the interpreter, and there are two interpreters, the sender and the receiver.

Cure," on the other hand, is not "improvement," unless you particularly expect your slide down the mountain to return you permanently to a higher altitude.

Try to be sure you and everyone else know what your words mean.

[pdpatient]

Roy, I hope that you are kidding. There's no guarantee of a cure for either Cancer or Parkinson's. I am not sure that with 7.8 billion people in this fast deteriorating planet, we would want any. Just saying.

At least with Parkinson's, we don't have to deal with a death sentence.

[VALENTINE28 in reply to pdpatient]

Bonjour,

Vous répondez

« Au moins avec la maladie de Parkinson, nous n’ont pas à faire face à une condamnation à mort. »

Je ne suis pas du tout en accord avec vous car évidemment que cette maladie est une condamnation à mort.... puisqu’il n’existe pas à ce jour de traitement pour guérir cette maladie. (sauf cas exceptionnels pour certains malades qui sont sortis ou qui voient leur maladie stagner) .. Je crois au contraire qu’imaginer l’issue difficile de cette maladie est un vrai cauchemar pour les proches aussi...

[pdpatient in reply to VALENTINE28]

Google Translation:

Hello,

You reply:

“At least with Parkinson's disease, we don't have to face a death sentence. "

I do not agree with you at all because obviously this disease is a death sentence ... since there is currently no treatment to cure this disease. (except in exceptional cases for some patients who have left or who see their disease stagnating) .. On the contrary, I believe that imagining the difficult outcome of this disease is a real nightmare for loved ones too.

————————————-

Hi Valentine, thank you for your reply. I appreciate your perspective and you are entitled to your opinion. However, how you observe life and live it, can and will determine the course of the disease and ironically, it can become a death sentence.

My opinion is that in Cancer at least in a large number of cases, unless you catch it very early, you are probably left fighting for your life and cancer drugs exist to help fight the disease. Unfortunately, in most of the cases i have observed in those among my friend and family, it is a lost or losing battle. Some people do survive, for example, my father was diagnosed with very early stage oral cancer and was immediately operated upon and continued to live cancer free for 15 years.

I believe and this is my opinion and my doctor’s statement, that unless i do something incredibly stupid, like walk on the edge of a cliff or try to free scale a mountain, I will likely die from my diabetes before Parkinson’s kills me!

I implore you to adopt a positive attitude and try to live with purpose. There are 7.8 billion people on this planet and you and i are lucky to be still breathing :).

————————

Google Translation:

Salut Valentine, merci pour ta réponse. J'apprécie votre point de vue et vous avez droit à votre opinion. Cependant, la façon dont vous observez la vie et la vivez peut déterminer et déterminera l'évolution de la maladie et, ironiquement, cela peut devenir une condamnation à mort.

Mon opinion est que dans le cancer, au moins dans un grand nombre de cas, à moins que vous ne l'attrapiez très tôt, vous vous battez probablement pour votre vie et des médicaments contre le cancer existent pour aider à combattre la maladie.

Malheureusement, dans la plupart des cas que j'ai observés chez mes amis et ma famille, c'est une bataille perdue ou perdue. Certaines personnes survivent, par exemple, mon père a reçu un diagnostic de cancer de la bouche à un stade très précoce et a été immédiatement opéré et a continué à vivre sans cancer pendant 15 ans.

Je crois, et c’est mon opinion et la déclaration de mon médecin, que si je ne fais pas quelque chose d’incroyablement stupide, comme marcher sur le bord d’une falaise ou essayer de grimper librement une montagne, je mourrai probablement de mon diabète avant que Parkinson ne me tue!

Je vous implore d'adopter une attitude positive et d'essayer de vivre avec un but. Il y a 7,8 milliards de personnes sur cette planète et vous et moi avons la chance de respirer encore :).

[MarionP]

Hi Roy. My daughter who died of cancer at age 38 this year after a 20 year battle, spanning the entire golden age you reference, including using the best and newest treatments (including invasive and not) therein derived, would like to discuss your groundbreaking new great idea with you. Look her up when you get to her neighborhood. If you return with an endorsement, we can talk about justified credibility. Let me know.

Faith in politicians just sounds like an idea for a new cult. But in the US a new "faith" can get favorable tax status. That's a start. In fact, gives me a new idea for a Go Fund Me drive, we could call it "Faith in Politicians."

[Hidden in reply to MarionP]

That sucks.

Still, there's few cancers i'd not rather have than PD. At least with (some) cancer you have a shot.

[VALENTINE28 in reply to Hidden]

Bonjour,

Je suis complet d’accord avec vous... au moins pour les cancers il y a la possibilité d’essayer un traitement alors que pour Parkinson ce n’est pas le cas.

[Parkie- in reply to MarionP]

Sorry to hear that.

Life's a bitch.

[pdpatient in reply to MarionP]

Sorry for your loss, Marion P. May her soul rest in peace.

[VALENTINE28 in reply to MarionP]

J’ai une pensée affectueuse pour vous car perdre un enfant ne devrait pas exister...