Can someone explain :Does the parkinson's glove therapy assume we don't have a loss of Dopa. Neurons but they just need to be reorganized. Via vibration
Where gene therapy assume we have a loss of Neurons that need to be replaced ?
Which is it, replace or reorganize?
My extremely limited understanding is that it's both. From listening to Dr. Tass, he seems to recognize that there is loss of dopamine, but that isn't the full picture - there is also a pathological synchrony of neural circuits. Desynchronizing those seems to be what he is going for and it is that that provides relief to the patients.
Personally, I think the loss of dopamine is an oversimplified view of PD - or that it's just one sub-type. I'm guessing that research over the next few years will show that it's much more complex than just dopamine loss and replacement and that we'll see an expanded definition of PD and different sub-types of it.
I agree 100 %. I don‘t understand why all the research starts with the assumption that it is only a loss of dopamine. Obviously that has not done anything to cure or halt Parkinson’s.
Ablation has been used since 1939. DBS authorised by the FDA since 2002. The "more complicated than dopamine loss" is not going to be a new discovery. But whereas Parkisonisms can arise from brain injury or drug side effects, Parkinsons Disease is only capable of conclusive diagnosis by an autopsy - which shows...
The death of dopamine neurons in the substantia nigra!
It is the very definition of the disease. Of course, dopamine replacement , dbs & Fus only address motor symptoms. The mechanism that drives the death of dopamine neurons in the SN, also damages neurons in the gut and autonomous nervous system, olfactory bulb, seratonin neuons et al. Finding that mechanism is the key to a really good solution
it seems that once there is an orthodoxy, making any dent in such entrenched positions is a monumental endeavor. Humans seem to find security in our holding on to beliefs. Super frustrating and detrimental to ourselves.
No. The glove therapy has nothing to do with reorganising dopamine neurons.
Is the Parkinsons therapy glove available to buy or is it still in trials waiting to be approved by FDA?
Still in trials. Some Individuals are making their own gloves.
Interesting, thanks!
The "dead" neurons may just be inactive.
Good question! Basically I think since many people have a very strong reduction in symptoms when they take C/L, which essentially replaces dopamine, scientists have concluded that lack of dopamine is the essential problem for people with Parkinson's. But if that were the case, things like DBS and the gloves would not work. Clearly dopamine plays a roll, but I am not clear on why other methods involving electrical impulses and desynchronization would work. Wouldn't we still be deficient in dopamine and therefore not be able to pass signals to the rest of the body correctly? Clearly there is more going on here.
Astonishingly scientists know and understand a lot more than too many on this forum credit them with. Both the Sonimodul website and eric ahlskog book will answer your questions.In brief, loss of dopamine results in disrupted signalling in one brain circuit. This leads to an imbalance which can either be fixed by replacing the missing dopamine in the first circuit, or by disrupting the signaling in other circuits in the system. Disruption can be by physical lesion, which was the original technique and which is now generally achieved by Focussed ultrasound, or by electrical stimulation, whether by dbs or vibrotactile stimulation
Waking up dormant dopaminergic neurons to reverse Parkinson's disease
"Advances in stem cell engineering offer to replace what is lost in Parkinson's disease,"
Treg Cells Attenuate Neuroinflammation and Protect Neurons in a Mouse Model of Parkinson’s Disease. [This looks like an important article!]
COVID survivors may be at a greater risk of developing Parkinson’s–like symptoms, researchers warn. What to know to protect your health
NURR1: Facilitating the transition of neural stem cells into functional dopaminergic neurons.
