Gotcha you little **cker (Desulfovibrio i... - Cure Parkinson's

Cure Parkinson's

25,550 members26,870 posts

Gotcha you little **cker (Desulfovibrio in the Gut)

jeeves19 profile image
34 Replies

Excuse the expletive but I think were onto something here. Apparently it thrives in meat eating biome and does less well in plant based environments.

Bacteria have emerged as important pathobionts in the last few years and appear to be contributing factors in not only intestinal disorders but also in extra-intestinal diseases. This is exemplified by diseases such as Parkinson’s disease, where DSV appear to play a causal role in the formation of synuclein aggregates, a hallmark of PD. It also provokes the question of whether the association and involvement of DSV can be extended to similar diseases such as ALS, HT, or AD, where DSV may act as a common denominator in disease pathophysiology. Similarly, role of DSV in the development of atherosclerosis has been reported. Thus, mounting evidence suggests that DSV have multifaceted effects throughout the human body, extending beyond their influence in the gut. This also applies to all other intestinal and extra-intestinal diseases that are linked to gut microbial dysbiosis where DSV overgrowth may occur. While a few studies have revealed some cellular pathways by which DSV may mediate their effects, the underlying mechanisms of how DSV may affect these diseases remain largely unknown. Thus, future in vivo and in vitro studies should focus on determining the molecular mechanisms behind the effects of DSV on the host. As some DSV species appear to be more pathologically significant than others and because DSV isolated from patients have worse outcomes on recipient cells than the ones isolated from healthy individuals, it is critical to understand the structural (such as LPS), biochemical, and functional differences between DSV species. This may hold a key to identifying the target mechanisms that are unique to each of these species. It is also important to understand what host factors in patients (but not in healthy controls) may lead to increased pathogenicity of these strains. Overall, this information may be helpful in identifying novel therapeutic targets that could be utilized in the management or treatment of diseases that are associated with DSV bloom.

Written by
jeeves19 profile image
jeeves19
To view profiles and participate in discussions please or .
34 Replies
Grumpy77 profile image
Grumpy77

Hello Jeeves' What's DSV? Google search comes up with too many acronyms with none relevant to the context here.. Thanks

jeeves19 profile image
jeeves19 in reply to Grumpy77

He’s gotcha back Grumpy

Wind_in_the_trees profile image
Wind_in_the_trees

Desulfovibrio Bacteria Are Associated With Parkinson’s Disease

This has amazing info imho

frontiersin.org/articles/10...

Wind_in_the_trees profile image
Wind_in_the_trees in reply to Wind_in_the_trees

Glycomacropeptide is a prebiotic that reduces Desulfovibrio bacteria, increases cecal short-chain fatty acids, and is anti-inflammatory in mice

pubmed.ncbi.nlm.nih.gov/262...

jeeves19 profile image
jeeves19 in reply to Wind_in_the_trees

Where do you get it from? It seems that so far I can only get it from Whey Protein.

Wind_in_the_trees profile image
Wind_in_the_trees in reply to jeeves19

Lacprodan® CGMP-20

arlafoodsingredients.com/me...

?

evenshoshan profile image
evenshoshan in reply to Wind_in_the_trees

Hi Wind, how can one purchase it from abroad ? I tried contacting Arlafoods but it seems that they only deal with other companies. Any help would be appreciated.

Reetpetitio profile image
Reetpetitio in reply to jeeves19

Hi, where did you get to with this, i'm curious? Not queueing up to drink whey protein and wondering if you found an alternative? Does sound like an important prebiotic as I do eat meat...

jeeves19 profile image
jeeves19

Thanks very much

gomelgo profile image
gomelgo

So how does this explain that I was dxed with PD last year after being vegan for nearly 12 years?

jeeves19 profile image
jeeves19 in reply to gomelgo

you raise a good point. Interesting. That’s not to say that Diverforivbrio can’t inhabit a vegan intestine presumably

gomelgo profile image
gomelgo in reply to jeeves19

Or maybe DSV is a bit like alpha synuclein, in that it's not a cause but a symptom?

Wind_in_the_trees profile image
Wind_in_the_trees in reply to jeeves19

We need this

It tests your gut in great depth

functionalgutstore.com/shop....

evenshoshan profile image
evenshoshan in reply to gomelgo

One possible explanation could be that Parkinson’s is insidiously alive and kicking within us many years before the symptoms surface.

gomelgo profile image
gomelgo in reply to evenshoshan

Or it could be that PD is latent in EVERYONE, and if enough factors constellate, anyone can develop the shakes.

LAJ12345 profile image
LAJ12345 in reply to gomelgo

That’s my theory. Well something is latent in everyone, PD, Alzheimer’s, cancer heart disease etc depending on your particular genetics. Then lifestyle switches it on.

gomelgo profile image
gomelgo in reply to LAJ12345

Not just lifestyle, environment, and circumstances too.

LAJ12345 profile image
LAJ12345 in reply to gomelgo

Yes, I include those in lifestyle.

evenshoshan profile image
evenshoshan in reply to gomelgo

One possible explanation could be that Parkinson’s is insidiously alive and kicking within us many years before the symptoms surface.

gomelgo profile image
gomelgo in reply to evenshoshan

I was watching a little girl on the train the other day with her very young mom, completely ignoring her pleas for help with her winter jacket in 70 degree weather. The girl was about 2 or 3, and was struggling mightily, while her mom was busy reading text messages and admonishing her for trying to remove the hot garment ... I kept thinking, this is how PD (or whatever other deadly manifestation of grief) begins.

Wind_in_the_trees profile image
Wind_in_the_trees in reply to gomelgo

Please explain. Do you mean because of the ferritin discussed in the paper? That is sited as a source but perhaps not the only source? And the probiotic said to counter it is oddly sourced from whey, non vegan.

rebtar profile image
rebtar

how do I know if i’ve got the little monster in my microbiome?

jeeves19 profile image
jeeves19 in reply to rebtar

I can only presume that this bacteria caused your PD.

rebtar profile image
rebtar in reply to jeeves19

There are so many factors, I would think this is one, but not necessarily for everyone!!

LAJ12345 profile image
LAJ12345 in reply to jeeves19

I suspect it has many possible causes.

LAJ12345 profile image
LAJ12345 in reply to jeeves19

we do meat, vege, fish, vege nights so I think it might help keep bugs in check as they can’t get settled in as the bean and lentil bottle brush sweeps them away every second day. It’s a theory at least😄

Wind_in_the_trees profile image
Wind_in_the_trees in reply to rebtar

functionalgutstore.com/shop....

jeeves19 profile image
jeeves19

you raise a good point. Interesting. That’s not to say that Diverforivbrio can’t inhabit a vegan intestine presumably.

evenshoshan profile image
evenshoshan in reply to jeeves19

One possible explanation could be that Parkinson’s is insidiously alive and kicking within us many years before the symptoms surface.

chartist profile image
chartist

We have had this discussion several times in the past on this forum and here is a link to one of those discussions that covered a lot of ground and revealed multiple remedies for this bacterial group :

healthunlocked.com/cure-par...

Here is a relevant quote from that thread :

' The third strain, Desulfovibrio piger is frequently seen as active in inflammatory bowel disease, so these look like three very bad players in the gut microbiome of some PwP, but are they the cause??? '

healthmatters.io/understand...

Green tea and turmeric seem to be natural inhibitors of this group.

Art

freefallmode profile image
freefallmode

Hi, just wondering if you had a source or more information for the idea that it thrives in meat eating biome and does less well in plant based environments? Thanks

jeeves19 profile image
jeeves19 in reply to freefallmode

Sorry, it was just something I read. The general consensus appears to be that turmeric, green tea and whey protein are certain foods that it doesn’t like?

WinnieThePoo profile image
WinnieThePoo

if only it were that simple

jeeves19 profile image
jeeves19

worth an ingest surely Rich? 😂

You may also like...

Desulfovibrio... More than a glimpse of hope

medicalnewstoday.com/articles/parkinsons-may-start-from-bacteria-in-the-gut?apid=32293354&rvid=e3b0c

Can Levodopa Contribute to Gut Dysbiosis via Increased Gut Inflammation and More Dysbiosis? The Study Below Suggests It Can

Gut dysbiosis seems to be very prevalent in people with PD and many other diseases or health issues...

Comprehensive coverage of gut health relevance and possible treatment for Parkinson

**Abstract:** The gut-brain axis and the microbiome play a pivotal role in Parkinson's Disease...

Interesting link to gut

interested in critical thoughts. Gut Inflammation Linked to Brain Disease Onset in Preclinical...

Gut bacteria and diet

Concerning the relationship of gut bacteria to PD, I'm suspicious that less refined foods, such as...