Animal trials - Investigators serious about treating Parkinson's make sure the test animal has Parkinson's before applying treatment

[park_bear]

Cases in point:

Inhibikase Therapeutics C-Abl inhibitor IkT-148009 science.org/doi/10.1126/sci...

"PD, IkT-148009 suppressed c-Abl activation to baseline and substantially protected dopaminergic neurons from degeneration when administered therapeutically by once daily oral gavage beginning 4 weeks after disease initiation. Recovery of motor function in PD mice occurred within 8 weeks of initiating treatment concomitantly with a reduction in α-synuclein pathology in the mouse brain." [emphasis added]

Inhibikase is running a phase 2 trial right now, but they're only accepting patients not taking medication. Further detail here: clinicaltrials.gov/study/NC...

Cinnamon

In this study: Reduction of Lewy Body Pathology by Oral Cinnamon link.springer.com/article/1...

Investigators used 10-month-old A53T mice. These mice are genetically modified to produce defective human alpha synuclein with the A53T mutation. Regarding these mice: alzforum.org/research-model...

"Moreover, around 10 months of age they begin to develop severe motor impairments (Lee et al., 2002). Early signs of impairment include wobbling and posturing."

My report on Cinnamon here: healthunlocked.com/cure-par...

[Moondaughter]

I am so weary of animals suffering....sigh

[jeeves19 in reply to Moondaughter]

Hear hear!

[jeeves19]

PB. This report of yours just sounds too good to be true! Usual $64k question: why haven’t more people picked up on this?

[park_bear in reply to jeeves19]

The power of publicity. Big Pharma has a marketing budget of $20 billion per year in the US alone. When a Pharma PR department issues a press release, it is picked up by mass media and usually repeated here on this site about five times in separate posts. Cinnamon does not have a PR department.

[jeffmayer]

How do u know if a mouse has pd

[park_bear in reply to jeffmayer]

journals.plos.org/plosone/a...

[jeffmayer in reply to park_bear]

Thanks now it makes sense

[MBAnderson]

Rats. Once again they discriminate against the old guy. "30 Years to 75 Years (I'm 77.)"

Thanks p_b