AI suggests anti-histamines with C/l

[House2]

The study objective was to use artificial intelligence to rank the most promising repurposed drug candidates for PD. Natural language processing (NLP) techniques were used to extract text relationships from 33+ million biomedical journal articles from PubMed and map relationships between genes, proteins, drugs, diseases, etc., into a knowledge graph. 

The relationship patterns among the identified adjuvant candidates suggest that the likely therapeutic mechanism(s) of action of antihistamines for combatting the multi-factorial PD pathology include counteracting oxidative stress, amending the balance of neurotransmitters, and decreasing the proliferation of inflammatory mediators. 

pubmed.ncbi.nlm.nih.gov/375...

[Ghmac]

My understanding is that the antihistamines exhibit the capacity to synergistically alleviate Parkinsonian symptoms when used with dopamine modulators like levodopa or levodopa-carbidopa. So just with the PD drugs. Has AI done anything in reference to PD patients who are not taking drugs?

[Esperanto in reply to Ghmac]

Although this is an adjunct to C/L medication, previous research has also shown the link of histamine and occurrence of PD. The related more recent research by the "Dutch Brain Institute" and the planned follow-up study with anti-histamine is also not related to C/L. These studies are named in my post "PD link allergic rhinitis like "hay-fever" and histamine":

healthunlocked.com/cure-par...

[Shlim]

Hmmm...kind of makes sense. I think they use the same ingredients to make meth. Caution, oral PH balance, tooth/gum decay and addiction.