NMN NR Graphic

[House2]

1.   In a healthy neuron,  the enzyme NMNAT2 keeps the ratio of NAD > NMN  above the threshold that activates the neurodegenerative pathway, SARM1.

2.   In an unhealthy neuron, the enzyme NMNAT2 becomes deficient and is unable to maintain the ratio of NAD > NMN above the threshold for SARM1 activation.  This triggers SARM1 driven axon degeneration.

3.   Oral supplementation of NMN, into a system with healthy levels of NMNAT2, will lead to the conversion of NMN to NAD and help to maintain a healthy neuron (inhibits SARM1 activation).

4.   However, in a compromised neuron, oral supplementation of NMN will quickly saturate the depleted NMNAT2 enzyme, causing alteration of the ratio of NMN to NAD to exceed the threshold for SARM1 activation. Triggering axon degeneration.

5.   Supplementation with NR, that is converted to NMN, presumably “gates” the levels of NMN and maintains the ratio of NMN to NAD below the threshold of SARM1 activation.

[Bolt_Upright]

Thanks for explaining why NR does not activate SARM1 like NMN does. I am sticking with the cheaper NA (I love the flush!).

[Gioc in reply to Bolt_Upright]

Bolt_Upright,

😊😊😊 Anche io.

I ❤️ flush

IMO The good and old niacin (nicotinic acid flush type , B3 NA) does everything much better and it's cheap.

Greetings from Italy.

Gio

Anatra

[Bari2000]

what does of Nad is needed to take?

[Bolt_Upright in reply to Bari2000]

You might want to join the weekend Zoom calls that Marc is so kind to host and we could discuss NAD:

us02web.zoom.us/j/833522248...

Saturdays, 7 PM – 8 PM-ish, US Central Daylight Time (GMT–6.)

Sundays, 11 am – 12 PM-ish, US CDT.

[Little_apple]

Excellent explanation. I never sent your other work to Do Not Age as I had said I was going to. But this is so to the point and I understand it well enough to back it up. May I use it in my email?

[House2 in reply to Little_apple]

of course