Anyone tried Black Seed Oil?

[John_morris71]

Black Seed Oil (Nigella Sativa) has Thymoquinone and has many good properties. There are a lot of articles available that highlight the benefits of Black Seed Oil.

Here is a sample

acta.bibl.u-szeged.hu/62036...

Thymoquinone prevents neurodegeneration against MPTP in vivo

model of Parkinson’s disease and modulates α-synuclein aggregation

in vitro

Mustafa T. Ardah, Madiha Mohieldine Merghani and M. Emdadul Haque*

Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, PO Box -

17666, Al Ain, UAE

*E-mail: [e-mail]

Parkinson's disease (PD) is a common neurodegenerative disease, characterized by

progressive dopaminergic neurodegeneration with concomitant increase in oxidative

stress and subsequent neuroinflammation in the substantia nigra pars compacta (SNc)

of the midbrain. Studies are currently focusing on targeting neuroinflammation and

oxidative stress to effectively treat PD. This study evaluated the neuroprotective effect

of TQ, one of the active compounds in the black seed, against 1-methyl-4-phenyl

1,2,3,6 tetrahydropyridine (MPTP)-induced PD mouse model. Here, TQ treatment for 1

week (dose, 10 mg/kg b. wt.) prior to MPTP (25 mg/kg b. wt.) was performed. MPTP

administration caused decreased activities of superoxide dismutase, catalase and

depletion of reduced glutathione, with a concomitant rise in the lipid peroxidation

product. It significantly increased pro-inflammatory cytokines and elevated

inflammatory mediators such as COX-2 and iNOS in the striatum. Immunohistochemical

analysis revealed dopamine neuron loss in the SNc area and decreased dopamine

transporters in the striatum following MPTP administration. However, TQ treatment

significantly rescued dopaminergic neuronal loss and dopamine transporters. TQ

treatment further prevented glutathione depletion, inhibited lipid peroxidation, and

attenuated pro-inflammatory cytokines. TQ also reduced the increased levels of

inflammatory mediators, such as COX-2 and iNOS. In vitro analysis found that TQ

significantly inhibits α-synuclein aggregation and prevents cell death induced by pre-

formed fibrils. Thus, TQ not only scavenges the MPTP-induced toxicity but also

prevents α-synuclein-fibril formation and associated toxicity

[park_bear]

Black seed oil may be helpful however the study is not an indication of efficacy because they used an invalid model of Parkinson's disease: "TQ treatment for 1 week ... prior to MPTP ... was performed."

See here for detail as to why this is so: healthunlocked.com/cure-par...

[John_morris71 in reply to park_bear]

The focus should be on Thymoquinone , the main component of Black Seed Oil.

[Ashti]

We don’t use the oil, but we grind the seeds and it is a component of our daily spice mix, as we try to add nutrient rich foods to our daily life. All the spices are taken in quantities similar to what would be used if cooking or baking with them. The seeds, also known as black cumin, are added for their anti-inflammatory properties - so not PD specific, though I am happy to hear about potential PD benefits.