Fascinating Read: Mitochondria-Microbiota Interaction in Neurodegeneration 2021

[Bolt_Upright]

Mitochondria-Microbiota Interaction in Neurodegeneration 2021 frontiersin.org/articles/10...

Alzheimer’s and Parkinson’s are the two best-known neurodegenerative diseases. Each is associated with the excessive aggregation in the brain and elsewhere of its own characteristic amyloid proteins. Yet the two afflictions have much in common and often the same amyloids play a role in both. These amyloids need not be toxic and can help regulate bile secretion, synaptic plasticity, and immune defense. Moreover, when they do form toxic aggregates, amyloids typically harm not just patients but their pathogens too. A major port of entry for pathogens is the gut. Keeping the gut’s microbe community (microbiota) healthy and under control requires that our cells’ main energy producers (mitochondria) support the gut-blood barrier and immune system. As we age, these mitochondria eventually succumb to the corrosive byproducts they themselves release, our defenses break down, pathogens or their toxins break through, and the side effects of inflammation and amyloid aggregation become problematic. Although it gets most of the attention, local amyloid aggregation in the brain merely points to a bigger problem: the systemic breakdown of the entire human superorganism, exemplified by an interaction turning bad between mitochondria and microbiota.

[Smittybear7]

Is there a solution? What tests need to be taken to determine if there is a problem in the gut? It has taken me over 6 months to get my PCP to order a stool analysis and bloodwork. Neurologist and movement specialist deferred to the PCP .Sad state of affairs. Thanks for sharing.

[Bolt_Upright in reply to Smittybear7]

The best I can think is to peruse that article once and a while and take tips from it. One thing I am going to do is get back on my firm Specific Carbohydrate diet: healthunlocked.com/cure-par...

[Smittybear7 in reply to Bolt_Upright]

Thank you!

[LAJ12345 in reply to Smittybear7]

the solution I think is an ultra strict diet regime with plenty of prebiotic veges, plus fermented foods, and eliminate pesticides, sugar and additives.

[Smittybear7 in reply to LAJ12345]

Thank you!magnesium citrate and vitamin c worked for the past 2 days. I appreciate your advice.

[Bolt_Upright in reply to LAJ12345]

My second attempt at making a salad. I don't know what I'm doing wrong.

Salad

[Gioc in reply to Bolt_Upright]

Maybe it lives?!

But he's nice. 😁😁

Salade with glasses

[Bolt_Upright in reply to Gioc]

LOL

[LAJ12345 in reply to Gioc]

Love it

[Stillstandingstill]

That's a great article and it ties a lot of things together.

[Smokeypurple]

Thanks Bolt

'systemic breakdown of the entire human superorganism' !!!

Motivation rekindled. Great article.

[chartist]

Bolt,

Some how, all roads seem to lead us right back to the gut microbiome no matter how long or curved the road. The breakdown seems to occur there and grow from there, or at least that seems to be the direction that newer studies are pointing. This all happens with age as does the decline of melatonin in the body and gut microbiome in an inverse relationship.

Art