LL-37, a natural antimicrobial molecule present in the brain and gut, Suppresses Alpha-synuclein Clumping in Parkinson’s

"LL-37, a natural antimicrobial molecule present in the brain and gut, selectively binds to harmful clumps of the alpha-synuclein protein — a hallmark of Parkinson’s disease — and prevents their further aggregation and toxic effects in lab-grown nerve cells, a study shows."

parkinsonsnewstoday.com/202...

[Hidden]

not sure if relevant to this

"Short-term treatment with 2000 IU/day vitD significantly increased 25(OH)D levels in CD patients in remission and it was associated with increased LL-37 concentrations and maintenance of IP. Achieving 25(OH)D ≥ 75 nmol/l was accompanied by higher circulating LL-37, higher QoL scores and reduced CRP. Registered at ClinicalTrials.gov (NCT01792388)."

journals.sagepub.com/doi/fu...

[Bolt_Upright in reply to Hidden]

That looks relevant! So what is the best vitamin D on Amazon!

[Despe in reply to Bolt_Upright]

Vitamin D3K2 by "Farmacy," but not on Amazon.

[Leslim in reply to Despe]

Have u tried the Vitamin D... and does it slows the PD?

[Despe in reply to Leslim]

My husband takes 10,000 IU and I take 2,500 IU. Vitamin D, combined with Magnesium and Calcium, is good for everyone's bones.

[Feargaire in reply to Bolt_Upright]

Hi. I use Life Extension D3 + K2 from iHerb. I started on 2x per day for two weeks to ramp up plasma levels. And reverted to 1x per day thereafter. A Magnesium supplement may be advised as D3 & Mg are involved in calcitonin production. A lack of the latter and it will be sequestered from other sources to achieve calcitonin production.

[Tonia1952]

where and when can we buy the priduct?

[slimweiss in reply to Tonia1952]

Try Mercola.com. I get most of our supplements from him because he does a lot of research and uses only quality ingredients without harmful fillers . His VIt D is great. He’s not the cheapest but I think it’s worth it.

[Rhyothemis]

Michael Lustgarten's book Microbial Burden has a section on LL-37 (costs $5):

smile.amazon.com/Microbial-...

Also has a lot on LPS and references some PD related studies.

[MarionP]

Any critical remarks? Lemmings and little birds abound, and as a fan I seem to feel in the position of educating doctors, but what do the more informed have to say?