Melatonin bad for me

[Victor1975]

Better sleep but I get worse with 3mg melatonin. 15 days after starting the treatment I began to feel more stiffness and more tremors. I have 3 days without taking melatonin and still feel bad. any recommendation ?

[Hmop]

Бихте ли ми казали какви лекарства и добавки приемате, които са помогнали да се подобрят симптомите на Паркинсон?

[ElliotGreen]

I'm sorry you're hitting this bump in the road. People react to medications and supplements differently, so it's good to listen to your body and your experience.

I don't have much advice. There's one thing that I will mention just in case it is relevant.

There is one sleeping medication (zopiclone??) which I once was prescribed which had something like "muscle fatigue and weakness" on its list of possible side effects. I took this medication alongside melatonin for a couple of days. I have the Bradykinesia form of Parkinson's (low movement) suddenly my symptoms were worse. It freaked me out.

Fortunately, I found mention on an obscure forum that melatonin can exacerbate the sleeping drug's muscle weakness side effect.

I stopped taking the drug (and continue taking the melatonin) and my movement return to what it had been before.

Your experience and situation may be different.

Melatonin is usually considered safe, but it does do a few different things in the body, and again, it may affect different people differently.

[PNIAuthor60]

My son with early onset recommends Sleepy Time Tea or Chamomile Tea as they will both relax the body using two bags instead of one. He has the same consequence when using Melatonin

[Sydney75 in reply to PNIAuthor60]

Melatonin exacerbates my HWP RLS

[PNIAuthor60 in reply to Sydney75]

oh and what do those initials mean, Sydney sorry not familiar with them

[Bolt_Upright in reply to PNIAuthor60]

Husband With Parkinson's and Restless Leg Syndrome.

[chartist]

Melatonin is available down to 300 mcg. Perhaps you should start lower to see what dose is optimal for you so you can get better sleep without side effects. Here is a typical product :

amazon.com/Life-Extension-M...

Art

[park_bear]

I am unable to tolerate melatonin because it causes me a gassy diarrhea and I am not the only one. There are other good non-prescription disease modifying treatments for Parkinson's.

[Esperanto in reply to park_bear]

But, if a smaller dose helps you fight insomnia, then mild side effects (for me headaches) are sometimes preferable. Sleep is probably still one of the best PD drugs.

[rescuema in reply to Esperanto]

Melatonin never helped my insomnia at any dose and tends to worsen it actually whenever I tried. I find it interesting to hear that it works for others because it doesn't for any of my friends/family. It probably provides benefits for those who don't produce enough of the hormone on their own.

"While Dr. Denniston explains that melatonin may be used successfully for those with jet lag, occasional restlessness, and irregular sleep schedules, someone who's losing sleep due to stress and anxiety may not be able to feel its effects. "A lot of time people with low-grade anxiety have a hard time falling asleep, so a supplement that helps them relax is a better option than melatonin, because they likely already produce enough," she says. "

thezoereport.com/p/why-does...

[rescuema in reply to park_bear]

That's very interesting PB. At what dose do you notice those symptoms?

Taking melatonin seems to make me feel more wired even at a low dose. Interestingly enough, I've been supplementing raw CLO along with Cu separated from all other supplements in order to improve copper enzymes activity, but major gassy diarrhea and feeling wired with sore kidneys were one of the copper dump symptoms I experienced in the beginning. I'm starting to think melatonin mobilizes Cu along with other toxic metals for those who tend to respond badly to melatonin.

[park_bear in reply to rescuema]

As I recall I was taking around 10 mg. For more detail there are about six pages of comments on the subject here:

healingwell.com/community/d...

If mobilizing toxic metals were the cause I would think this would abate after some time. However, this can go on a month or more when people do not suspect melatonin is the cause.

[rescuema in reply to park_bear]

It can take years to eliminate copper toxicity from the body and it can be quite problematic if mobilized and reabsorbed while ceruloplasmin is depressed. I'm still battling through it and it's been months though the dump symptoms are getting less intense.

Thanks for the link. I'll take a look.

[rescuema]

The 3mg dose isn't large enough to make me wonder if you're experiencing a detox/mobilization/chelation (ie copper) effect, but I do wonder if your melatonin includes B6 as most tend to. If so, you may want to visit this recent thread. If one is B6 toxic already, they respond terribly to any additional B6.

healthunlocked.com/cure-par...

[Victor1975 in reply to rescuema]

The one taken is without B6. First time that I hear about detox/mobilization/chelation (copper) effect. I m going to search about that

[rescuema in reply to Victor1975]

You never heard it mentioned because the idea is mine. Melatonin is a powerful antioxidant that can chelate copper, so it is also possible to tip the balance. Check out the mentioned B6 thread for relevant Cu discussions also.

ncbi.nlm.nih.gov/pmc/articl....

researchgate.net/publicatio...

[chartist in reply to Victor1975]

Melatonin can chelate some heavy metals and help protect against the damage caused by heavy metals through multiple methods of action, so it may be a worthwhile consideration during chelation therapy.

Art