A Stem Cell Story Which Encourages Me, But Also Infuriates Me.

[jimcaster]

This is old news. This successful stem cell experiment took place more than FIVE YEARS AGO! It encourages yet infuriates me. We slowly deteriorate while something so incredible is right under our nose.youtu.be/cN2ZgSStm7I(Not working as expected?)

[Drummer67]

Hi Jim, I so agree with you. I simply am at a loss for these procedures moving so slowly when they seem like the answers to our dreams.

[RooJr]

agreed!

[Baron1]

The only way to ""Fast Track" this type of procedure and have it available for all patients within 24 months is to call Parkinson's Disease - COVID.

Then you will see Governments around the world throwing money at Pharmaceutical companies to make IPSc stem cell procedures available for all.

Why were Vaccines fast tracked for COVID?

Vaccines are not 100% cures, they do not stop the virus, they just give people a better chance of survival.

So Stem Cell treatment is the same, it gives people a better chance of surviving; right?

YES.

[Boscoejean]

research continues and it appears that some progress is being made

businesskorea.co.kr/news/ar...

genengnews.com/neurological...

this article is about ALS but in the last paragraph it suggests that the research could also be helpful in Parkinson's

alsnewstoday.com/news/new-w...

[SilentEchoes in reply to Boscoejean]

1) I see a lot more overlap in PD/ALS drug trials. They are related, although no one wants to admit this.

Thanks for sharing 😊

SE

[SilentEchoes in reply to Boscoejean]

2) I tried autologous stem cell transplant, little benefit and short lived. This might be why, "iPSC-derived neurons generally do not reach full maturity, and they do not survive very long."

I think there's a better chance with umbilical stem cells, you need to go to Panama for that.

[Manypony in reply to SilentEchoes]

I had cord cell in Seattle. No noticeable effects

[SilentEchoes in reply to Manypony]

My was Intranasal. Yours was a riskier procedure.

[Manypony in reply to SilentEchoes]

I remember half intranasal and half intravenous

[Boscoejean in reply to SilentEchoes]

where was this being done?

[SilentEchoes in reply to Boscoejean]

Florida, my neurologist had to consent. Insurance isn't accepted.

[Boscoejean in reply to SilentEchoes]

I was expecting that insurance would not cover this just because it seems like insurance does not cover much other than medications and surgery

[Nikosmom in reply to SilentEchoes]

I’m from Panama living in Florida. Please explain

[SilentEchoes in reply to Nikosmom]

In a Panama stem cell clinic with American doctors, they are using embryonic stem cells from cord blood with supposed good results. Can't do this in the US. Cost is something like $30,000 USD per treatment. The stem cell transplant I had was from my own bone marrow and was injected intranasally. It was half the cost.

[Nikosmom in reply to SilentEchoes]

thanks for your reply. I will investigate.

[Nikosmom in reply to SilentEchoes]

What were your results?

[SilentEchoes in reply to Nikosmom]

Temporary improvement of autonomic function. Could be different with more advanced practices, like embryonic stem cells.

[Gioc in reply to Boscoejean]

hi Boscoejean, Thanks for the very interesting references

“Northwestern University-led researchers have created the first highly mature neurons from human induced pluripotent stem cells (iPSCs). Although previous researchers have differentiated stem cells to become neurons, those neurons were functionally immature, resembling neurons from embryonic or early postnatal stages.”

This is a big step forward, but it reveals how far there is still to go. Every good engineer knows that he has to make sure he knows the function before modifying the structure of a complex machine. We still know little about the complex functions of neurons to transplant cells and hope they do the job. This research makes that very clear. But the solution is not a matter of time but first of all what you want, of intelligence, of the quantity of coordinated efforts. We PWPS are involved in point one. Want! and it is not difficult since the current alternative is not pleasant for us.

Greetings from Como lake Italy.

Gio

Tree

[SilentEchoes]

Each person with PD is a "million dollar baby" why would the cartel want to cure you?

[WinnieThePoo in reply to SilentEchoes]

That is desperately sad self-pity and naeivity. But hardly new on this forum. John pepper is it's champion. Like any conspiracy theory it depends on your ability to believe in a global conspiracy. James Bond and Blofeld. Father Christmas and the elves. It doesn’t really stand up to close scrutiny. Big and little pharma are looking for the solution they can wipe the floor with. Not sustaining a budget generic manufacturers drab cash flow

[SilentEchoes in reply to WinnieThePoo]

I don't understand your comment.

[Missgirly117]

Dream Body Clinic in Puerto Vallarta is doing stem cell treatment. We’ve talked to them. He says it’s not a cure, but could help with symptoms. We’ve thought about it, but would like to see some success stories before we spend 5K. Would be a nice vacation though!

[jimcaster in reply to Missgirly117]

As eager as I am for stem cell therapy to be readily available, I would not go to Mexico or anywhere else which is not approved by the FDA. Be careful.

[SilentEchoes in reply to jimcaster]

Mine was registered as an open clinical trial. My neurologist okayed it but didn't think it would be helpful. He was right and we are many thousands of dollars poorer.

[Boscoejean in reply to SilentEchoes]

okay so this is interesting- do you know the clinical trial number? I am interested in reading what their goals were and how they were trying to accomplish them

[Farooqji]

I am anxiously looking forward to the outcome of Kyoto university Japan stem cells trial. It was initiated in 2018. I had contacted it's main scientist Jun Takahashi. He told me that they are keeping it confidential and the outcome is expected in 2024. It's availability on commercial scale will be by year 2028 if successful

[kaypeeoh]

The body stores stem cells in sub-q fat. The cells can be extracted via liposuction then injected into diseased tissue. As a veterinarian I experimented, with the client's consent, to inject stem cells into a dog's stifle joint. This is the same as the human's knee joint. The dog had bilateral ACL damage and was cured with the treatment. The dog weighed 150#. Surgery is the only thing known to help but it costs $15,000. The liposuction and stem cell extraction cost me pennies and rebuilt the dogs torn ACLs. I don't know whether the same procedure might work for a person with PD but it's worth thinking about.

[JAS9]

So... what's in it? She certainly doesn't "explain everything". Diving down this rabbit hole, I found a study that reports that certain peptides can signal stem cells to activate and supports them afterward. It's here: ncbi.nlm.nih.gov/pmc/articl...

There seem to be several competing and less expensive products, which isn't surprising. I think this one looks interesting, for example: lifeextension.com/vitamins-...

[kevowpd]

Jim, you are capable of a more rigorous analysis than this.

One of the challenges with this situation is that the team has had difficulty generating IPSC cells of the quality they think they need. Refer to the instagram post of about 12 weeks ago. Furthermore, whether or not this is actually 'incredible' remains to be seen, since you can make videos saying pretty much anything, and much of the recent information about this has come via sources other than journal articles.

[WinnieThePoo]

Just to add my 2 penn'th to Kevowpd's comment, as you know, I share your frustration, and would love a surefire transplant therapy to be available affordably (for those of us in Europe, that means free ) TODAY. No several weeks ago - today is too casual.

But I grew up with the news full of thalidomide babies, and the history of PD therapies is littered with in-vitro, fruit fly, rat, mouse, monkey and phase 2 human success, only to bomb for one reason or another at phase 3

If we had read the early reports of the pioneering transplant work in PD at the end of the millenium, we'd have been writing posts like this one

And the result would have been nature.com/articles/news030...

It's clear a lot of progress has been made since that early experiment, but people like Roger Barker, who know their stuff, and share our impatience, understand there is a need for proper evaluation, so it is not just safe, but significantly effective

Maybe we should sign up for a conspiracy theory , that "they" want to keep us ill, show contempt and hostility to hard-working dedicated researchers, trial participants and scientists, and wallow in self-pity, and assurance that we can find better in a few herbs . Declare Ernst Blofeld and SPECTRE are running global pharmaceuticals.

Or sign up for Zhittya - have you noticed how they have ramped up their search engine optimisation - including getting hits on stem cell searches, and will offer you their untested miracle cure today if you don't mind it being completely untested. (Edit - sorry Zhittya, tested on one monkey by somebody else a quarter of a century ago)

Or be a prize sucker and go to a private stem cell clinic like Swiss Medica, and pay a fortune for an overpriced, risky, unproven (as in doesnt work) but exotic procedure.

What more could you ask?

There's stuff coming - and hopefully it will bridge the wait (I would have thought a minimum of 5 years, more likely 10) before stem cell transplants are a clinical reality.

Ernst Blofeld and cat from the James Bond movies

[Zardoz]

Are we sure that it was/is a success? It happened 5 years ago. Has there been a follow up to see if the good results held? Has the specific procedure been used successfully with another patient?