CBD & Cannabis :evidence of neuro protection in PD

[Little_apple]

frontiersin.org/articles/10...

The molecular mechanisms associated with CBD's improvement in PD and AD are likely multifaceted, and although CBD may act on different molecular targets all the beneficial effects are in some extent linked to its antioxidant and anti-inflammatory profile, as observed in in vitro and in vivo studies. Therefore, this review describes evidence to prove the therapeutical efficacy of CBD in patients affected by neurodegenerative disorders and promotes further research in order to better elucidate the molecular pathways involved in the therapeutic potential of CBD.

michaeljfox.org/grant/role-...

funded in 2020

Levels of CB2 receptors are increased in the brain of people with Parkinson's; however the exact role of CB2 in Parkinson's is not clear. This project aims to investigate how targeting CB2 alters the behavior of immune cells involved in aggregation, or clumping, of the protein alpha-synuclein.

sciencedirect.com/science/a...

(Not sure if C. Elegans is worth considering)

Neuroprotective effects of cannabidiol on dopaminergic neurodegeneration and α-synuclein accumulation in C. elegans models of Parkinson’s disease

salk.edu/news-release/canna...

Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells

mdpi.com/2227-9059/10/12/3000

2022 from Croatia

Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential

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Thank you.

[Missy0202]

Thank you for all this great info. I did a clinical trial years ago. 20:1 CBD:THC. I didn't finish the trial because I could not get to the 1ml dose. I plateaued at .75ml and have stayed at that dose for the last 2.5 years. Although I didn't see a change in PD symptoms, it definitely helps with sleep.