Plasmalogens: suggests that plasmalogens may serve as potential therapeutic intervention for multiple neurodegenerative diseases

[Little_apple]

frontiersin.org/articles/10...

[garygjs]

Don't think this was posted in the previous plasmalogen discussion:

hindawi.com/journals/pd/202...

Introduction. Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). With the ageing of population, the frequency of PD is expected to increase dramatically in the coming decades. L-DOPA (1,3,4-dihydroxyalanine) is the most effective drug in the symptomatic treatment of PD. Nonmotor symptoms in PD include sleep problems, depression, and dementia, which are not adequately controlled with dopaminergic therapy. Here, we report the efficacy of oral administration of scallop-derived ether phospholipids to some nonmotor symptoms of PD. Methods. Ten (10) patients received oral administration of 1 mg/day of purified ether phospholipids derived from scallop for 24 weeks. Clinical symptoms and blood tests were checked at 0, 4, 12, 24, and 28 weeks. The blood levels of plasmalogens in patients with PD were compared with those of 39 age-matched normal controls. Results. Initial levels of plasma ethanolamine ether phospholipids in PD and ethanolamine plasmalogen of erythrocyte from PD were lower than those of age-matched normal controls. Oral administration of 1 mg/day of the purified ether phospholipids increased plasma ether phospholipids in PD and increased the relative composition of ether phospholipids of erythrocyte membrane in PD. The levels of ether phospholipids in peripheral blood reached to almost normal levels after 24 weeks. Furthermore, some clinical symptoms of PD improved concomitantly. Conclusion. 1 mg/day of oral administration of purified ether phospholipids derived from scallop can increase ether phospholipids in peripheral blood and concomitantly improve some clinical symptoms of PD.

[garygjs in reply to garygjs]

Incidentally, it seems that folk gravitate towards either NeuroRegain or Goodenowe's precursors when it comes to buying this stuff. There's another - less expensive - option: DHC plasmalogen...likely available on Ebay and certainly available through a number of Japanese online stores (eg Takaski). 1mg/ day dose. I trust it's an appropriate standard. DHC has a pretty solid reputation ( in cosmetics, principally).

[Little_apple in reply to garygjs]

excellent info

Thank you!

I am motivated to try it