Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action

[Bolt_Upright]

I really want to transition from research to recovery, but this does look interesting: Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action 2022 sciencedirect.com/science/a...

I found Emodin because it inhibits EBV: pdfs.semanticscholar.org/06...

But it seems to do so much more. Just scroll down to "6.2. Parkinson's disease"

[Astra7]

Interesting. It seems easy enough to buy the supplement. I might try it - I’ll let you know how I get on.

[Zella23]

Interesting read, thanks for posting. It appears also to activate the Nfr2 pathway. Also mentions about liver toxicity, with higher doses so proceed with caution I would say.

[PDWarrior1900]

thanks for the links... within the first one... scrolling down to 6.2 -- it reads:---------------------------------------

"Oxidative stress and mitochondrial dysfunction were once thought to be the key contributors in PD pathogenesis, but studies have since then established genetic factors to be the primary culprit for the initiation and propagation of the disease."

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i thought genetic factors affected only 10% to 20% of PWP ... what's your opinion?

[Bolt_Upright in reply to PDWarrior1900]

Good catch. What is odd is that the reference they seem to be using to make the case PD is primarily genetic is from 1994: bmj.com/content/308/6923/281

I am skeptical about that paragraph.

[Gigi216 in reply to Bolt_Upright]

This study says B12 modulates one of the genes that increases risk

ncbi.nlm.nih.gov/pmc/articl...

[Bolt_Upright in reply to Gigi216]

But not any B12. Looks like I am taking the wrong B12

"Interestingly, we found that only AdoCbl, but not the other forms of vitamin B12, exhibited inhibition of LRRK2-G2019S autophosphorylation in MEF cells with an IC50 of ~10 µM, similar to that measured in vitro (Fig. 1f–g). We observed a similar inhibition profile for the different forms of vitamin B12 in macrophages derived from the LRRK2-G2019S transgenic mice (Supplementary information, Fig. S2d). The lack of inhibition displayed by CNCbl, HOCbl, or MeCbl is not understood at present, but one possibility is that differences in cellular uptake, localization and metabolism in the cells may affect their efficacy compared to AdoCbl. Because AdoCbl showed the greatest potential for LRRK2 inhibition in cultured cells, we focused our efforts on this physiological form of vitamin B12."

[Gigi216]

Says it’s found in Japanese Knotweed, I’m taking that at the moment

[Bolt_Upright in reply to Gigi216]

I searched for Japanese Knotweed and fell down a rabbit hole!

A SCIENCE-BASED PROTOCOL TO SLOW OR STOP PARKINSON’S DISEASE

by Dr. H. Gordon Ainsleigh, D.C. gordonainsleigh.com/Parkins...

He actually has some reasonable things in his protocol, but also says to drink beer or wine every morning through to the afternoon. He seems to do what others do in drawing protocols based on studies.

He also has a protocol for AD and recommend Lithium. That was from 2013, so he was ahead of the curve: DR GORDY’S KEEP-YOUR-WITS PROTOCOL

PREVENTING & TREATING BOTH ALZHEIMERS AND VASCULAR MEMORY LOSS gordonainsleigh.com/Alzheim...

[Gigi216 in reply to Bolt_Upright]

Hmm wouldn’t let me read it, says 404 not found

[Bolt_Upright in reply to Gigi216]

Odd. You can go to this page and then click on the PD and AD protocols: gordonainsleigh.com/publica...

[Gigi216 in reply to Bolt_Upright]

That one works!