Recently, after many attempts over the last 15 months to find my optimal daily oral dosage of B1 HCL per Dr. Constantini's B1 Protocol, trying dosages between 1,200mg and 3,500 mg/day, I’ve decided to cease taking oral B1 and try sub-lingual B1 instead. My reasoning for giving up on oral B1 is as follows: Like many who suffer from Parkinson's, I have frequent and chronic constipation, and I think that this may "muddy the waters" when it comes to finding an optimal oral dosage of B1, because for me and those like me, there is no single optimal dosage. If, for instance, I'm not constipated at all, my optimal dosage might be 1,500mg/day. If semi-constipated, it might be 2,200 mg, and if extremely constipated, it might be 3,500 mg/day. In other words, a dosage which is fine on one day might be either too little or too much on another, depending upon the level of intestinal blockage.
Is there anyone else on Dr. Constantini's B1 Protocol who is having similar problems?