N-DOSE: A Dose Optimization Trial of Nicotinamide Riboside in Parkinson's Disease

clinicaltrials.gov/ct2/show...

Brief Summary:

N-DOSE is a double-blinded placebo-controlled randomized trial aiming to determine the optimal biological dose (OBD) of nicotinamide riboside (NR), in individuals with Parkinson's disease (PD).

The investigators recently reported the NADPARK study (ClinicalTrials.gov: NCT03816020), a phase I randomized, double-blinded trial, assessing the tolerability, cerebral bioavailability and molecular effects of NR therapy, 1000mg daily, in PD. The NADPARK study showed that NR 1000mg daily was well tolerated and led to a significant, but variable, increase in cerebral NAD (nicotinamide adenine dinucleotide) levels (measured by 31phosphorous magnetic resonance spectroscopy, 31P-MRS) and related metabolites in the cerebrospinal fluid (CSF). NR recipients showing increased brain NAD levels exhibited altered cerebral metabolism, measured by 18fluoro-deoxyglucose positron emission tomography (FDG-PET), and this was associated with mild clinical improvement. The results of the NADPARK trial nominate NR as a potential neuroprotective therapy for PD, warranting further investigation in larger trials. The investigators recently conducted the NR-SAFE safety trial comparing 3000mg NR to placebo in 20 participants with PD over 4 weeks (NCT: NCT05344404) which showed no moderate or severe adverse events, and no signs of acute toxicity.

Due to the variability in response to NR in the NADPARK trial, the N-DOSE study will investigate the response to escalating doses of NR from 1000mg to 3000mg over 12 weeks, in order to ascertain the optimal biological dose of NR in PD.

Links:

* NAD-PARK

clinicaltrials.gov/ct2/show...

* NR-SAFE

clinicaltrials.gov/ct2/show...

* N-DOSE

clinicaltrials.gov/ct2/show...

[jimcaster]

Wow. I thought 1,000 mg seemed like a lot, but if 3,000 is better, I guess I will consider it. However, the benefits need to be quite evident to justify the cost. The most potent pills I know of are 300 mg. I currently take 3 daily.

[Missy0202 in reply to jimcaster]

me too

[Fumaniron]

Agreed that's a big dose!

[Gcf51]

Has anyone done a study on which increases NAD the most "Nicotinamide Riboside", NMN, or Niacin