If I was to take two things one to help mitochondria and one to help with inflammation , which would be the most helpful . Thank you, Maria 🌺
Mitochondria/ Inflammation advice - Cure Parkinson's
Mitochondria/ Inflammation advice
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akgirlsrock
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48 Replies
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healthline.com/health/infla...
Looks interesting! Thanks for sharing.
Thanks for sharing!
Are you only looking at food sources? Melatonin, B1 Thiamine, Nicotinic Acid, Turmeric D3 and many others have the same benefits
Really good question but a tough one to answer because several things need to be right to keep the mitochondria supported.Inflammation is easier....most of the time inflammation is often a flareup through bad diet choices, too much sugar, too much yeast, too much omega 6 , not enough omega 3, not enough nitric oxide creating food.Beets...green leafys...fishoil high in EPA DHA...
Mitochondria ...here goes....if you take statins....you may end up with memory fog...and muscle pain because cholesterol feed both brain and muscle which is where mitochondria are in abundant supply.....you need to offset with coq10 ...the better of the two is ubiquinol because it is more bioavailable.
Pomegranate and cranberry seem to work almost as well as the very expensive akkermansia...if inflammation and poor gut motility cause poor uptake of nutrients.
If he is overweight, he should look into mitochondria uncoupling...this seems counter productive because intermittent fasting improves the health and life span of mitochondria.
Magnesium improves the ATP switching in the mitochondria ...melatonin (3mg) will restore rest and repair of anyone with sleeping issues....then there is autophagy...removing poor functioning mitochondria by using fisetin and quercetin...mitochondria repair at night...of course there are many more thoughts out there on this....look into Dr David Sinclairs work on this via Youtube...food for thought!...best wishes.
• in reply to
Excellent summary. Very hard to summarize such a complex subject. Do you think Fisetin and Quercitin should be used intermittently , hit and run approach for autophagy or at a lower dose but more indefinitely?
Regarding too much omega 6, for those of us who already have very healthy diets, I wonder if nuts and seeds are too high in omega 6 and should be eaten only on occasion?
I have found ginger to be exceptional at lowering inflammation.
• in reply to
Fisetin should be used for about 5 days then leave for a couple of months...mosts cells replace approx every 60-90 days...so thats a good yardstick..every two to three months have a five day window on fisetin...strawberry extract is better than sumac....quercetin can be used without negative effects for months...it is a polyphenol....good alround around anti inflammatory anti oxidant.Omega 6 needs to be included but balanced, flaxseed oil is a far superior omega 3 and much better at reducing inflammation....also you can “activate” omega 3 by adding a lowdose junior aspirin now and then.
• in reply to
I have been doing a 5-7 day course of Fisetin once a month maximum. I don’t know what dosage is optimum for such a short duration.“strawberry extract is better than sumac”
So finding Fisetin sourced from strawberries over sumac? I think that’s what you meant?
I’ve never used flaxseed oil. I will seek it out. Thank you for the information.
For anyone interested:
Dr. James Kirkland is my favorite source for learning about Fisetin.
And Dr. Mark Matson for fasting to induce autophagy is a good source.
• in reply to
Very helpful,thankyou.
JAS9• in reply to
I'm largely in agreement with all your comments, Jomico. I do have just a few nit-picky things. First, flaxseed oil is notoriously difficult to keep from oxidizing. Instead, store unprocessed flax seeds (which keeps them 'fresh' indefinitely) and grind them (a coffee grinder works fine) once a week. Keep the ground flax seeds refrigerated in an air-tight container. Consume 1-2 tablespoons a day. The flavor is buttery and very pleasant, so you can mix it into many different things, like oatmeal, salad dressing, etc. Not only do you get fresh flaxseed oil, but you also get the benefit of more fiber. In general, less processing is better.
Also, should we take aspirin to "activate" omega-3? I see that a recent study found a benefit in doing that, but "new research found that the risks of daily aspirin begin to outweigh the benefits starting at age 60. Specifically, the risk of aspirin causing potentially life-threatening bleeding in the brain or gastrointestinal tract increases with age. A review of the literature found that the incidence of these bleeding complications outnumbered preventive effects for people over 60 without established CVD."
theportlandclinic.com/daily...
• in reply toJAS9
Yes i agree..flaxseed will oxidise so shelf life is about 3 months...The advice on using aspirin was specifically every other day...not every day..at junior dose...which is given to older people as a daily precaution after strokes and heart related issues...so quite safe.
I read the report it seems ambiguous and unclear, one sentence it say one thing , then it infers it may be okay...mights and maybes without clear longterm studies are often generated by people tied to big pharma..just a thought.
People with inflammation often have thicker blood so i think it was fairly good suggestion...unless of course they happen to be taking blood thinners.Incidentally fish oil, olive oil and flaxseed “thin” blood too...but those who do not take these as part of a regime tend to end up having clots strokes etc...i am happy to remove all my postings on this thread.
• in reply to
I hope you won’t remove them. Not even scientists are spot on 100% of the time. All of this has so many layers, caveats, and nuances. Everything you said is to my knowledge correct but discussing other options is valuable. Regarding thinning the blood, I think one of the reasons Vinpocetine and Ginko biloba increase blood flow to the brain is via thinning it so they could be potential alternative options.
JAS9• in reply to
No need to remove your posts. I'm learning from you, and I hope that by giving you feedback, you *might* learn from me. If I'm wrong about something please correct me, otherwise, I'll go on believing something that is incorrect or has nuances that I haven't considered.
• in reply toJAS9
I learn everyday...that i still do not know enough, and thank you for your thoughts...sharing is the way forward.
• in reply toJAS9
Regarding oils, agreed. Sesame is great to grind at home too. I do take fish oil but have reservations about it and therefore alternate my source and eat fish roe (which is gross.) ☺️
JAS9• in reply to
Ugh. Fish oil and roe. I get all of my omega-3 from plant-based sources. For example, I take this supplement:
vitacost.com/deva-vegan-ome...
This avoids or at least reduces the risk of consuming so many toxins! Some people mistakenly believe that omega-3 from fish is different somehow, but all of the omega-3 in existence has originated in plants (algae, flaxseed, etc.). Fish don't manufacture it; they eat other fish, which have eaten other fish, and so on until some fish eats algae, which contains omega-3s.
So I avoid all of the middlemen (middle fish?).
I take Thorne fish oil which I understand is tested for mercury and heavy metals. Are there other toxins to be aware of?
Take weed killers, such as glyphosate (the active ingredient in Roundup) which is still *somehow* legal in the US and has been linked to several cancers. It breaks down extremely slowly, is liquid, and literally tons of it makes its way to the ocean or other bodies of water. When the federal govt's own posters say: "Some fish, such as larger carp, catfish, trout, and perch, are more likely to have fish advisories due to mercury or other contaminants." My next question is "what are these other contaminants"?
• in reply toJAS9
Oh my goodness, very good point. Yipes
• in reply toJAS9
Very good explanation!! As a former vegetarian (almost a vegan) I HATE ingesting the fish oil. But there is such a proliferation of encouraging information for fish oil for brain health that I take it as an insurance policy. But goodness I would prefer your supplement! It states “grown in a controlled environment.” 😀.
But then it’s only 180 mg of DHA. So I would need 6 a day.
How many do you take?
JAS9• in reply to
I've been taking 2 a day. Why do you take so much? I don't remember why I settled on 2/day.
• in reply toJAS9
Based on some doctors whose info I have read and listened to and a trial in the UK. I will work on finding my sources and circle back to this. Im endeavoring to better organizing my research process.
I eat a fair amount of nuts and seeds and las labs showed too much omega 3, not enough omega 6! I take fish oil, eat a lot of greens and other veggies, nuts and seeds, olive oil etc. My dr said I could increase omega 6. Still have inflammation though. Hm. Any ideas of other ways to reduce? I think it’s stress/worry, mostly subconscious. Starting serious qigong practice.
• in reply torebtar
I have very stubborn inflammation. I believe you are also no cow dairy? What about grains and legumes? What about inflammatory oils? Due to very stubborn inflammation I have had to go gluten and cow dairy free (other than ghee) and almost no grains or legumes. 1/4 cup of grains a week max. And my only legumes are cashews and peanut butter.
Maybe you could try a break from grains and legumes and then test inflammation again?
I also fast. This week I’m trying alternate day fasting for the first time.
JAS9• in reply to
CC, here's a link to a list of good sources of omega-3, including legumes. One small warning: legumes (peas, beans, and lentils) are called different things in various parts of the world, so just double-check to be sure you're ordering what you think you are. For instance, "mung" is in the name of 2 different legumes, but "Urad dal" is always urad dal, and has a very good omega-3/omega-6 ratio. That's what I put into my favorite chili.
rebtar• in reply to
Have you been able to reduce inflammation with your diet? I eat minimal sugar, occasional grains and legumes but not much, almost no dairy or gluten. I had reduced all of those strictly for a few years, but my inflammation markers were still pretty high. I've loosened up a bit because I was being obsessive and perfectionist as a fear response to my symptoms, which I think contributes to underlying stress. I usually don't eat between 8pm and 10am. Alternate day fasting can be stressful for the body as well. I'd like to hear how it goes for you.
Yes, and no or almost no inflammatory oils. I think I'll get my inflammation markers tested again soon. If they've gone up, I'll return to a stricter diet...
• in reply torebtar
All those changes and your inflammation was still high. Hmmm. I fear I may be in the same situation. Do you do a home test for inflammation? Ginger?
Oh, and I remember you eat kiwi skins. I started too. But then paused due to oxalates.
Regarding the fasting being hard on the body, in what way? I’ve done 3 1/2 days and then I called it quits. I’ve slowly worked up to this. I obviously don’t like it but am hoping it’s Neuroprotective. It is according to Dr. Matson of the NIA
LAJ12345• in reply to
When you test for inflammation is that a blood test? Which one?
Look at the usual suspects if your omega 3 intake is already high, yeast, bread, any form of sugar, underlying infections, low thyroid issues.Stress depletes magnesium, essential mineral for 300 functions within the body.
Flaxseed oil (omega 3)is better at reducing inflammation.
Some adaptogens may help....ashwaghanda, tumeric, andrographis(low grade infections) olive leaf extract.
rebtar• in reply to
I do have underlying infections and am treating them bit by bit (olive leaf extract, etc.). Thyroid is fine. Lots of magnesium. I have increased carb intake somewhat, but it's not much. I do not eat flaxseed oil but I can include it in my morning smoothie no problem. I still think stress is a big player.
rebtar• in reply to
Taking both turmeric and ashwaganda.
MarionP Thankyou for your input, could you share your source?...obviously you have information to prove inflammation is not helped by foods that shown to reduce inflammation, this would be helpful.
The romans used quercetin and olive leaf as antibiotic and antiinflammatories, long before pharmaceuticals invented antibiotics...they must be kicking themselves for being so stupid.
Ari Whitten has just run another series of videos on energy and it focuses on the mitochondria. I’d dearly like to take his personal course but of course it’s more money. The free videos were very interesting though . I am not sure if they are still up. Here is a photo of one of his slides on causes of dysfunctional mitochondria.
Causes of mitochondrial dysfunction
Here are the video links
theenergyblueprint.com/ener...
Part 4 and sales pitch for his personal,program.
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