Saw this on NewsMax newsmax.com/health/dr-blayl... and decided to find the original report. Including the NewsMax link as it tells us N-hexacosanol is in wheat germ.
A diet low in animal fat and rich in N-hexacosanol and fisetin is effective in reducing symptoms of Parkinson's disease pubmed.ncbi.nlm.nih.gov/228...
"This study describes how foods rich in fisetin and hexacosanol added to a strict diet reversed most symptoms of Parkinson's disease (PD) in one patient. This is a case report involving outpatient care. The subject was a dietitian diagnosed with idiopathic PD in 2000 at the age of 53 years old, with a history of exposure to neurotoxins and no family history of PD. A basic diet started in 2000 consisted of predominantly fruits, vegetables, 100% whole grains, extra virgin olive oil, nuts, seeds, nonfat milk products, tea, coffee, spices, small amounts of dark chocolate, and less than 25 g of animal fat daily. The basic diet alone failed to prevent decline due to PD. In 2009, the basic diet was enhanced with a good dietary source of both fisetin and hexacosanol. Six months after the patient started the enhanced diet rich in fisetin and hexacosanol, a clinically significant improvement in symptoms was noted; the patient's attending neurologist reported that the clinical presentation of cogwheel rigidity, micrographia, bradykinesia, dystonia, constricted arm swing with gait, hypomimia, and retropulsion appeared to be resolved. The only worsening of symptoms occurred when the diet was not followed precisely. Little improvement in tremor or seborrhea was observed. The clinical improvement has persisted to date. To the best of our knowledge, this is the first case where adjunctive diet therapy resulted in a significant reduction of symptoms of PD without changing the type or increasing the amount of medications. "
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Did a little more research on Fisetin and found this article: Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review
Neurodegenerative disorders pose a significant health burden and imprint a debilitative impact on the quality of life. Importantly, aging is intricately intertwined with the progression of these disorders, and their prevalence increases with a rise in the aging population worldwide. In recent times, fisetin emerged as one of the potential miracle molecules to address neurobehavioral and cognitive abnormalities. These effects were attributed to its actions on several macromolecules and multiple molecular mechanisms. Fisetin belongs to a class of flavonoids, which is found abundantly in several fruits and vegetables. Fisetin has manifested several health benefits in preclinical models of neurodegenerative diseases such as Alzheimer's disease, Vascular dementia, and Schizophrenia. Parkinson's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Stroke, Traumatic Brain Injury (TBI), and age-associated changes. This review aimed to evaluate the potential mechanisms and pharmacological effects of fisetin in treating several neurological diseases. This review also provides comprehensive data on up-to-date recent literature and highlights the various mechanistic pathways pertaining to fisetin's neuroprotective role.
Highlights
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Fisetin increases AcetylCoA, a precursor for central glycolysis and Acetylcholine synthesis leading to memory enhancement.
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Fisetin increases phosphorylation of ERK, CREB Promoting long term potentiation.
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Fisetin regulates advanced glycation end products leading to increase in long term potentiation.
This is available in supplement form, some forms are lipsomal similar to how glutathione is best absorbed. I would have to purchase article to see what amount was used in study.
From the fulltext of the study the estimated daily intake of fisetin was 24 milligrams, well covered by any of the 100 milligram supplements. Or six ounces of strawberries daily per the study.
The hexacosonol part of the diet was in microgram quantities obtained from wheat germ. So it could have been some other component of the wheat germ, or even just the fisetin, that made the difference.
Hi Astra7 it looks like a pretty complete product, not sure about bioavailability. The review on the website are mostly about aging well, more energy, etc. I am not sure what this means in term of quality of product regarding testing. AEON is also currently undergoing additional testing for distribution at Kroger, and Target which is scheduled to begin in 2022 including Heavy Metal Analysis, Packaging Test, and Microbial Limits Test, and we will be publishing the results shortly.
It is cheaper on manufacturer's website than Amazon if you set up a monthly delivery.
Hi Astra7 I emailed the company that makes this supplement and asked about bioavailability. This is their response, seems positive:
Thank you for your interest in AEON. Our Fisetin is combined with a galactomannan compound from frenugreek seeds to help inhibit it from becoming inactive, and we use capsules that make it through the first phase of digestion to facilitate absorption. Each ingredient tends to have a slighltly higher absorption rate with specific foods, but they are so diverse that we just recommend takng AEON with a meal for best results.
I like that the supplement has many other good components and may eliminate some pills. Worth a try for a month. Note: autoship is $10 less per bottle.
Thanks. Very interesting. I also like the combination. It contains many things I was told to take by my integrative GP, but she had me on so many supplements I felt that pill taking was my life. It was also very expensive. I stopped most of them after buying at vast expense what turned out to be essentially clay !
I’m sure she had shares in the pharmacy next door!
Hi. I tried a bottle but didn’t notice any improvement. It’s so difficult to know if I took a high enough dose for long enough, but unfortunately no miracle improvements 🙁
Because it's oil-soluble (not water-soluble), I stir it into a little EVOO and put it on a salad. There are also fisetin supplements that have "enhanced bioavailability". I take Doctor's Best which uses something called "Novusetin" (and I also combine it with EVOO). There are others. If someone figures out which is best, please let me know.
I've been taking 100 mg of Fisetin supplements every day, with only about three weeks off of it since then. It's inexpensive and easy to find. Hexacosanol was hard to source at the time, and I didn't want to eat so much wheat germ, so I haven't.I was already eating the diet described in the report (except I eat no animal products at all and no processed/added sugar). I've stuck to it ever since. Has this helped me? I have improved over the last few years (in my subjective opinion) but it's hard to say what's helped because I try so many things. I also do red light therapy with my coronet 2-3 x a day, for example.
About 2 years ago, my neurologist noticed some "improvement" and said, "I wish all of my 12-year PD patients walked as well as you do." Haven't seen her since due to the pandemic and because I haven't needed to. My symptoms are probably a little better now. OTOH, my "improvement" in symptoms over the last few years has been accompanied by a slight increase in my Rytary. I don't see my neurologist very often, so she doesn't really know what's currently going on with me. Is that strange? Now that I've typed it, it seems strange. I guess I should go back to get her opinion.
Since starting Fisetin about 3 years ago, I increased the dose of my daily meds just once by about 8%. But during the 3 years before that, I'd had to increase it by an average of 12% a year. So, more stable but not completely stopped.
I have read the Fisetin has very poor bioavailability. Are you taking it with anything that increases the absorption? No animal products ... that's tough good for you. Nevermind I just read above. We can try that to make it more bioavailable.
Another video on Fisetin, but this one is focused on senescent cells and aging. Interesting dosing suggestion: similar to the advice given for other molecules that trigger autophagy, this suggests taking a much larger dose of Fisetin intermittently (e.g. 3 days on and 11 days off). The idea is to switch between the two states of cellular "repair" and "autophagy". It may make sense; it's generally accepted that cycling between these two states creates a better balance. You don't want to be recycling cells all the time; you also need a period of building them up.
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