Inflammaging, Kynurenine pathway , tryptophan

How does the Kynurenine pathway effect our neurological homeostasis and lack of homeostasis?

scienceofparkinsons.com/202...

Rescuema pointed me towards this SOP and I’m reposting bc as she always does, she pointed me towards some great info to increase my understanding of the complexity of neurology.

frontiersin.org/articles/10...

Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype known as inflammaging that is involved in many age-related diseases. Activation of tryptophan (Trp) metabolism along the kynurenine (Kyn) pathway prevents hyperinflammation and induces long-term immune tolerance. Systemic Trp and Kyn levels change upon aging and in age-related diseases. Moreover, modulation of Trp metabolism can either aggravate or prevent inflammaging-related diseases.

Presently reading this article. I highly recommend.

[rescuema]

This concise video may help to see the big picture.

youtu.be/NznTdW311oU?t=47(Not working as expected?)

You can deduce how addressing inflammation (gut, brain, oral, etc), reducing stress, and meditative practice could help towards suppressing the overactive neurotoxic branch of the Kynurenine Pathway that leads to the accumulation of toxic metabolites and avoid tryptophan depletion.

Be nicer, avoid stressful interactions, exercise regularly (counters stress hormones), and practice gratitude every day to embrace more positivity.

🤗 🙏

[Hidden in reply to rescuema]

youtu.be/NG6klMym5lo(Not working as expected?)

[rescuema]

An interesting hypothesis on why you should seek out joyful activities.

"Paul knew his young grandson was in danger.

"Out of the corner of my eye I could see this little figure moving," he says. The figure was heading for a steep flight of stairs.

But what could he do? Paul was sitting down. And after more than a decade of living with Parkinson's disease, getting out of a chair had become a long and arduous process.

But not on this day.

"Paul jumped up from the chair and ran to my grandson," says his wife, Rose. (The couple asked to be identified by only their first names to protect their medical privacy.) "I mean, he just got up like there was nothing and ran to pick up Max." Amazing...

Our hypothesis is that there's another circuit that's intact, and that this circuit isn't affected in Parkinson's disease...

It's engaged by our sense of reward, by the joy of doing something"

npr.org/sections/health-sho...

news.ucsb.edu/2022/020583/p...

news.engineering.pitt.edu/s...

[laglag in reply to rescuema]

Loved the links, especially the first one. I read the second article about dancing & boxing.

Thought provoking for sure.🧘 🥊💃🕺

[rescuema in reply to laglag]

I always think of you whenever I hear "boxing." I almost even bought a VR boxing game after hearing how it helps Michel0220 because you're the inspiration for "Rock Steady Boxing."

🥊🥊👍

[laglag in reply to rescuema]

Thank you so much!

[Hidden]

Tryptophan metabolism has also been found to get altered in SD and it is linked to various neurodegenerative diseases. The kynurenine pathway is a major regulator of the immune response. Adequate sleep alleviates neuroinflammation and facilitates the cellular clearance of metabolic toxins produced within the brain, while sleep deprivation activates the enzymatic degradation of tryptophan via the kynurenine pathway, which results in an increased accumulation of neurotoxic

journals.sagepub.com/doi/fu...