L-Tryptophan, it should be in your stack (Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond)

[SilentEchoes]

L-Tryptophan metabolism through the kynurenine pathway is involved in the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in tryptophan metabolism in disorders ranging from cancer to neurodegenerative disease have stimulated interest in therapeutically targeting the kynurenine pathway.

L-tryptophan is an essential amino acid that regulates protein homeostasis and plays a role in neurotransmitter-mediated physiological events. It also influences age-associated neurological alterations and neurodegenerative changes.

The metabolites and enzymes of tryptophan influence a variety of physiological and pathological outcomes of the majority of systems, including endocrine, haemopoietic, gastrointestinal, immunomodulatory, inflammatory, bioenergetic metabolism, and neuronal functions.

The imbalanced state of kynurenine pathways has found a close association to several pathological disorders, including HIV infections, cancer, autoimmune disorders, neurodegenerative and neurological disorders including Parkinson’s disease, epilepsy and has found special attention in Alzheimer's disease.

Kynurenine pathway (KP) is intricately linked to neurodegenerative pathogenesis owing to the influence of kynurenine metabolites on excitotoxic neurotransmission, oxidative stress, uptake of neurotransmitters, and modulation of neuroinflammation, amyloid aggregation, microtubule disruption, and their ability to induce a state of dysbiosis.

This is just an abstract from which you can do more research. I found a brand on Amazon that is affordable and has only 2 ingredients. It's tested for heavy metals and pesticides.

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SE

[Smittybear7]

Thanks for sharing

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Tryptophan converts to seratonin. It is a fine delicate balance. Too much tryptophan can deplete dopamine. I would not generally recommend it for PWP. I have not recently researched this but I have in the past and am confident that a quick search of tryptophan dopamine will substantiate what I’m saying.

I leaned this when researching and concluding that 5 HTP would not benefit me at this time.

[Gioc]

Here’s another reason I use B3 niacin and not other forms of vitamin B3: tryptophan.

[CaseyInsights]

Trust you have done your homework, as 95% of Tryptophan supplementation goes down the Kynurenine Pathway.

It is described in one paper as Janus-Faced, in that it produces both neuroprotective (kynurenic acid) and neurotoxic (quinolinic acid) components.

So how do you get a balance that favours the neuroprotective components and suppress the neurotoxic. My research did not give a clear indication. And I gone through a couple of papers as I have used this stuff: focused more on the pathway that leads from Tryptophan > 5HTP >Serotonin > Melatonin.

But I suspect that heavy supplementation with B2 and B6 - major cofactors to the enzymes on this pathway - will be crucial in getting a neuroprotective outcome.

I am on pause until I understand more.

[SilentEchoes]

Thank you for weighing in in this.

SE

[SilentEchoes]

Please see conversions below

L-tryptophan