Grapefruit & Azilect safe together?

[Fumaniron]

Grapefruit and Azilect (MAO-B) safe interaction? Getting mixed input on web search. Looking at some supplements, and occasionally grapefruit pops up in the ingredients. Any thoughts appreciated. Thanks!

[House2]

Grapefruit uses a specific liver detoxin enzyme pathway, drugs that are cleared from the bloodstream by that same enzyme system, can't be cleared, accumulate and can reach toxic levels. I would avoid grapefruit.

[MarionP]

No, not particularly safe together, so when I feel like I would like a boost from having grapefruit, I just do it, as long as you don't do it too often or too intensely, it's like having an extra shot of caffeine to push your coffee along. As long as you don't become a junkie about it, it's not a bad thing. Yes those who know me as more of a scientist and someone who appreciates appropriate rigor, it doesn't make a lot of sense, but there you are, screw it. Dignity of risk is the phrase, and nobody's responsible for any outcomes but yourself.

[Fumaniron in reply to MarionP]

Well-stated

[Hidden]

When Azilect is taken with certain foods and medication, adverse reactions can occur. Consider the following precautions if you take Azilect:

a. Foods and beverages high in tyramine can cause high blood pressure. Signs and symptoms of marked blood pressure elevation include severe headache, blurred vision/visual disturbances, difficulty thinking, stupor/coma, seizures, chest pain, unexplained nausea or vomiting, or signs or symptoms of a stroke. Examples of food and drink with tyramine are: aged cheeses, air-dried meats, pickled herring, yeast extract, aged red wines, tap and draft beers, sauerkraut and soy sauce.

stanfordhealthcare.org/medi...

Grapefruit : 690 microgram of tyramine/gram of food

not the very worst according to list as follows

in microgram of tyramine/gram of food

* Pickled herring: 3030 * Beer yeast: 1500 * Cheddar: 1460 * Cabbage: 670 * Tuna: 570 * Gruyère: 514 * Chocolate: 500 * Tomato: 250 * Brie (a French cheeze): 180

[Fumaniron in reply to Hidden]

I have to be careful with the cabbage, and occasional cheddar. Thanks!

[Fumaniron]

Have to be aware of MAO Inhibitor activity of supplements, too. Including curcumin/turmeric, piperine, passion flower

healthfully.com/common-herb...

Apigenin Mao inhibitor

ncbi.nlm.nih.gov/pmc/articl...