Cannabis and its derivatives for the use of motor symptoms in Parkinson’s disease: a systematic review and meta-analysis

[Bolt_Upright]

Cannabis and its derivatives for the use of motor symptoms in Parkinson’s disease: a systematic review and meta-analysis 2021 journals.sagepub.com/doi/fu...

"Results:

Fifteen studies, including six RCTs, were analyzed. Of these, 12/15 (80%) mention concomitant treatment with antiparkinsonian medications, most commonly levodopa. Primary outcomes were most often measured using the Unified Parkinson Disease Rating Scale (UPDRS) among RCTs and patient self-report of symptom improvement was widely used among observational studies. Most of the observational data lacking appropriate controls had effect estimates favoring the intervention. However, the controlled studies demonstrated no significant motor symptom improvement overall. The meta-analysis of three RCTs, including a total of 83 patients, did not demonstrate a statistically significant improvement in UPDRS III score variation (MD −0.21, 95% CI −4.15 to 3.72; p = 0.92) with MC use. Only one study reported statistically significant improvement in dyskinesia (p < 0.05). The intervention was generally well tolerated. All RCTs had a high risk of bias.

Conclusion:

Although observational studies establish subjective symptom alleviation and interest in MC among PD patients, there is insufficient evidence to support its integration into clinical practice for motor symptom treatment. This is primarily due to lack of good quality data."

[SilentEchoes]

Check this guy out 🥰

youtu.be/7yWM4Br3BOI(Not working as expected?)

[Ponieboy]

Hi Bolt. I have been very curious about this subject. But I have serious concerns about cannabis use over all. I have a friend who uses it for PTSD issues and I have watched him gain no benefit. It actually has caused him more issues. His short term memory is having serious issues. His weight has increased significantly and he has become more dysfunctional. He basically smokes all day, does virtually nothing because of this and his coping skills have gotten worse. The results I have seen for people with PD has been mixed at best and temporary. It may provide some folks some temporary help but it comes with its own set of risk. I am the last person to judge anyone for trying it or using it but I want to see way way more info and research.

[Bolt_Upright in reply to Ponieboy]

That makes sense to me. That is kind of the result the studies showed too. No measurable benefit. Thanks.

[Ponieboy in reply to Bolt_Upright]

I have tried various CBD products and have had no real results for pain or sleep or even anxiety control...