Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALS Trial

[Bolt_Upright]

Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALS Trial clinicaltrials.gov/ct2/show...

They are doing 1 gram, twice a day.

[SilentEchoes]

Thank you for this!!SE

[Bolt_Upright in reply to SilentEchoes]

You are welcome. I was thinking of you.

[Bolt_Upright]

Looks like they did another trial using TUDCA earlier: Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis ncbi.nlm.nih.gov/labs/pmc/a...

"Results

Tauroursodeoxycholic acid was well tolerated; there were no between‐group differences for adverse events. The proportion of responders was higher under TUDCA (87%) than under placebo (P = 0.021; 43%). At study end baseline‐adjusted ALSFRS‐R was significantly higher (P = 0.007) in TUDCA than in placebo groups. Comparison of the slopes of regression analysis showed slower progression in the TUDCA than in the placebo group (P < 0.01).

Conclusions

This pilot study provides preliminary clinical data indicating that TUDCA is safe and may be effective in ALS."

[SilentEchoes in reply to Bolt_Upright]

The trial you linked was PIII, there must be something there. TUDCA works better with butyrate. This is one of those things that I think is universally benefitial for NNDs.

Just ordered Luteolin and Rutin. 🤞🏻

[Bolt_Upright in reply to SilentEchoes]

Luteolin. Interesting!

[SilentEchoes in reply to Bolt_Upright]

I know, right? I just posted about Butyrate, microbiome, autoimmunity and ALS, but really - substitute any NDD.

[Despe in reply to SilentEchoes]

Which Butyrate, by BODYBIO?

[SilentEchoes in reply to Bolt_Upright]

It's spendy, only need .25 tsp.

[Bolt_Upright in reply to SilentEchoes]

Which brand did you order?

[SilentEchoes in reply to Bolt_Upright]

On Amazon

Lutimax

[Despe in reply to SilentEchoes]

Excellent find, SE! Hubby takes Lutin to help with swollen ankles (and doing great now), why not get this supplement which has got both good antioxidants?

[Despe in reply to Bolt_Upright]

Bolt,

I really appreciate your searching for PD trials and supplements. You must spend considerable amount of time helping yourself and your fellow forum members.

[Trailing]

My husband has Parkinson's and experienced jaundice for a period. In doing research I came across TUDCA and its benefits. We were also considering the Restore Gold supplement from <wehaveparkinsons.com> at the same time and noticed that it contained TUDCA. When we went to order the Restore Gold they were out of stock. In talking with them we were encouraged to get the TUDCA separately till they were in stock again. We were so thankful as the doctor could find no cause for the jaundice and TUDCA is great for liver function.