Selegiline is Neuroprotective : According... - Cure Parkinson's

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Selegiline is Neuroprotective

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According to the article I will link below, Selegiline is Neuroprotective. I have read some of the actual studies concluding this but the link is a good summary.

I have read that selegiline is not compatible with some cold medicines. I have not determined if this would apply to Ambroxol and Montelukast. Does anyone know? (Ambroxol and Montelukast are believed to protective as well. This can be elaborated upon in a different thread.)

Also, regarding the extensive dietary restrictions when taking Selegiline, can those who have taken it please share their experience? No chocolate? No coffee?

(And John Pepper, respectfully sir, this is about Selegiline. We know you stopped it and why. Thank you.)

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laglag profile image
laglag

cc, you can look up drug interactions on this website. I'm taking Lexapro so I shouldn't take Segeliline. You can put a lot of combinations in, even more than 2 and it lets you know if they will interact with each other and if it's a low, moderate or high risk.

drugs.com/drug-interactions...

Because Ambroxol is not FDA approved, it is not included in the list. I will seek out a European site

Thank you!

laglag profile image
laglag

If you go down to See Also, it tells you the Major drugs you shouldn't take with Segeliline. There are 124. Most of them I haven't heard of but none the less I think it's a good reference.

healthunlocked.com/cure-par...

John Pepper stopped cuz of high blood pressure

healthunlocked.com/cure-par...

park_bear profile image
park_bear

mayoclinic.org/drugs-supple...

" When selegiline is taken at doses of 10 mg or less per day for the treatment of Parkinson's disease, there are no restrictions on food or beverages you eat or drink"

MerckK profile image
MerckK

I had been taking resagilline for last three years- 1 mg per day. Now my neurologist has stopped it and has prescribed Pecitane (THP) 2 mg a day. Resagilline with Premipaxole never created any problem with me except some skin allergies.

I consider myself a Foodie and my doctor never suggested for any dietary restrictions. I eat whatever I like.

The doctors treating me are the Professors and head of Neurology department of top government medical colleges.

Yes, all suggest good level of physical mental exercise

Elephantlydia profile image
Elephantlydia

An interesting review,it make you think.I would like this to be published in a peer review publication.

Raphaekg profile image
Raphaekg

See a literature update here. The previous article is old and cites old studies.

content.iospress.com/articl...

Selegeline is a highly selective MAO-B inhibitor. No need for dietary restrictions. Symptomatic benefits with (the study by Lee's being a singular exception) no increase in mortality.

I was just discussing the need for selegeline with my MDS after taking it for 12 years with levodopa. Symptomatic benefits seem clear. I constantly get warnings from every new pharmacist who notes that I take selegeline with a low dose (subclinical, better-safe-than-sorry ) SNRI. Yeah, the pharmacists' guidelines state that this is contraindicated. When I remind them that selegeline is a highly selective MAO-B-inhibitor, they say "okay, no problem " So don't get scared off by supposedly contraindicated drug interactions or dietary restrictions. No worries here (other than having PD, global climate disaster, the lingering pandemic, and the Russia/Ukraine situation, of course.)

JeanieBeanie profile image
JeanieBeanie

My husband has taken 10mg per day for 26 years and wouldn't go without it. He can tell if he has forgotten it. Never knew about the food exceptions. He doesn't suffer depression sometimes associated with PD. The trial Dr Lees did was flawed I understand because as PD is usually an older persons disease a lot on the trial were older anyway. My husband has been taking it since he was 45 and he is now 72.

TL500 profile image
TL500 in reply to JeanieBeanie

Has your husband on the same dose for all these years?Does it stop/slow down the progression?

Sounds like he has off time too?

Is it worse off time than time not taken meds? Thanks

JeanieBeanie profile image
JeanieBeanie in reply to TL500

The same 10 mg for all these years. Of course after 26 years his off times are worse. He has always been tremor dominant,hardly noticable when he is 'on', but bad when he is 'off'. I don't know if it has halted progression. He has had DBS. We go abroad 2/3 times a year until covid came. He does not get the depression associated with PD thankfully and I think this may be how silegiline helps. He thinks you should try it. First thing in the morning.

TL500 profile image
TL500 in reply to JeanieBeanie

Thanks for your reply. How long has he had DBS?

Does he have rigidity, slowness, weak muscles, balance, gait , turn in bed problems? T

JeanieBeanie profile image
JeanieBeanie in reply to TL500

Yes but after 28 years you would expect that and he is 72. He had DBS in 2005. He had to come off the dopa agonist because it was causing compulsive behaviour . Our local health authority paid for it to be done at Frenchay hospital in Bristol. It is more common here now and he goes to Sheffield now for his checkups which is much closer to us. Our nurse tells us DBS is really good now. Much easier than when my husband had it done.

kevowpd profile image
kevowpd in reply to JeanieBeanie

A lack of depression would tend, along with intact cognition, to suggest that he is one of the lucky relative few to have PD for several decades without material cognitive impairment. Well, maybe lucky is the wrong term but yknow.

JeanieBeanie profile image
JeanieBeanie in reply to kevowpd

Yes. Very lucky but it could be the silegiline.

kevowpd profile image
kevowpd in reply to JeanieBeanie

It could be, though that drug has been around long enough now that if there was a pattern of it staving of PDD/LBD, we would likely know about it. Probably a genetic difference, I'd day.

JeanieBeanie profile image
JeanieBeanie in reply to kevowpd

There is no evidence that it slows progression but my husband feels a difference if he forgets it.

Hikoi profile image
Hikoi

ccraspberryExcept for the title of the article there seems to be nothing much to support selegiline being neuro protective. What is more this is research from last century, over 30 years old. In that time we haven't had any more evidence that Selegiline is neuro protective.

This is a 1999 article which gives a completely different picture

medsafe.govt.nz/Profs/PUart...

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