Fasting for autophagy and decreasing plaques and misfolded proteins

Are any of you fasting? Can you share your experience?

There is a lot of science behind it’s anti inflammatory benefits.

I will work on accumulating my notes and links below.

[Hidden]

Interview with Dr. Ana Maria Cuervo - 72+ hours of fasting is believed to help clear out misfolded proteins.

youtu.be/xoof-mgMFYE(Not working as expected?)

[PDWarrior1900 in reply to Hidden]

WOWWWWW! THANK YOU THANK YOU THANK YOU for posting this!I'm on day #158 of O.M.A.D. and i've yet to 'nail down'.... when... autophagy starts...

I haven't watched this video yet... but YouTube has a series of autophagy videos with Dr. Ana and i will WATCH THEM ALL!!!

[MarionP]

Hey, enjoy the rush and make the most of it, but don't Burn Out, ok?

[Hidden]

I am really interested to hear experience with fasting. My symptoms get worse when I am hungry so I never tried fasting.

[rescuema in reply to Hidden]

Try a short term ketogenic diet if not fasting. Your body is not flexible using the alternative fuel source than glucose so fasting worsens your symptoms. There’s a reason why they call it a “keto flu” during the conversion period but once your body adapts to using ketones it’ll be a piece of cake to skip a few meals or fast and you won’t even feel hunger.

[Kizzmil in reply to Hidden]

Me too .I would like to find out more about fasting in helping pd

[Gioc]

IMO The best way to initiate an important flow of autophagia is heat, ie overheating the body through physical exercises or a hot bath without exaggerating, one hour or two. You NEED to be well fed, some vitamins and minerals, lots of water during exercise or a hot bath, once a day for a few days will bring the flow of autophagia to a hight level. Will it improve the symptoms of PD? I don't know, I plan to do a mix of light exercise and a warm bath with a vitamin and mineral mix in the next month.

For lovers of the genre here is a search.

ncbi.nlm.nih.gov/pmc/articl...

researchgate.net/publicatio...

[rescuema in reply to Gioc]

Even better, do a hot Epsom salt bath with an ice cold shower after.I do a few minutes of cold shower at the end of normal shower daily. It’s brutal nowadays because the water is seriously ice cold but you feel refreshed after.

[glenandgerry in reply to rescuema]

That's very brave! 😁

[rescuema in reply to glenandgerry]

Not as hard core as Dr. Wahls who takes 20 minutes ice bath! - it helps her sleep. Check out this video for a quick review of the benefits.

m.youtube.com/watch?v=-IvJ1...(Not working as expected?)

[kaypeeoh in reply to Gioc]

The article says, "...increase in autophagic activity in a dose-dependent manner in peripheral blood mononuclear cells (PBMCs)..." stimulated by heat. I use a cheap sauna. I don't know how high the temp goes but I feel the sweat dripping when I sit in it. Another thing I do is autohemotherapy. This is when blood is taken from a vein and injected into a muscle. The body treats the injected blood as a foreign body and mobilizes monocytes from the bone marrow to the peripheral circulation. I understand the body keeps 2% monocytes in the blood. After autohemotherapy the monocyte level rises to 22% for one week. By repeated autotherapy weekly the elevated monocytes can be maintained at the 22% level.

red light

[Gioc in reply to kaypeeoh]

Excuse me , kaypeeoh,

but why are you doing this?

🤔

[kaypeeoh in reply to Gioc]

I was diagnosed with MS a few years ago. I found a doctor who specialized in autohemotherapy then I found another doctor who says autohemotherapy will prevent lesions on the brain while not curing the disease. I think MS and PD are related conditions. So treating one treats the other.

[hmm777]

I do intermittent fasting daily (I eat only between noon and 6 pm) and periodically do 7-day water fasts where the only thing I eat is my Sinemet. (I tried even dropping the Sinemet once, but I do not recommend this.) I believe the fasting (both daily and long-term) is helpful, but like pretty much all of the alternative treatments discussed on this forum it's not for everyone and its mechanisms are not yet well understood. I recommend reading Jason Fung's book The Complete Guide to Fasting and trying shorter fasts to see if it's right for you. Be sure to segue into and out of a fast carefully; Fung is very good about providing simple rules for this.

A lot of people make wild claims about the magic of fasting and autophagy, but there is no way to tell outside of a very good lab (and maybe not even there) whether a particular method of fasting is really increasing autophagy in the brain, and even if it is we don't know for sure how much cleaning out the misfolded a-synuclein affects PD symptoms or progression. I can say that in my case, it seems to help quite a bit, but that might have as much to do with giving the gut a break from the labors of digestion as anything else. What Fung's book does seem to demonstrate is that fasting has been used by a number of cultures to effectively treat a lot of otherwise intractable health problems. Whatever metabolic and endocrine adjustments it stimulates (and I will not claim to fully understand these; no one does) have demonstrated benefits in a lot of situations.

If you want to dig deeper, I recommend reading articles and/or watching videos by Mark Mattson, a researcher at Johns Hopkins, former Chief of the Laboratory of Neurosciences at the National Institute on Aging, and I believe still the most cited neuroscientist in the world. He specializes in fasting and its effect on neurodegenerative disease, so he is obviously a great place to look on this topic. A couple of weeks ago he published a new popular book called The Intermittent Fasting Revolution which I have not read yet.

[amykp in reply to hmm777]

I eat strict keto all the time, do intermittent fasting most of the time (eat between about noon-7) and occasionally fast for longer (4-5 days--I've never made it to 7!)

Obviously I believe autophagy/mitophagy is a good thing, or I wouldn't be doing this, but, how good? My PD is very slow to progress, but, as I think I've mentioned in other posts, I am n of 1. I wish someone would do a serious study on it ... more than a couple months.

[Gioc in reply to hmm777]

Mark Mattson, a researcher at Johns Hopkins, former Chief of the Laboratory of Neurosciences at the National Institute on Aging

youtu.be/zb783zeWwHQ(Not working as expected?)

Thank, very interesting.

Gio

[JAS9]

Valter Longo, who is very experienced and knowledgeable about fasting, came up with a 5 Day program he calls Fasting Mimickng Diet. FMD tricks your body into reacting as though you are fasting even though you are not. It's related to keto, and you actually get into ketosis briefly, but you never experience the keto flu or feel like you're starving. He started the company called Prolon that sells prepackaged food for the diet, but when I do it I make my own meals. It worked well I think and I intend to do it again soon.

[Hidden]

Do you fasters take minerals or electrolytes?

Are there any you recommend?

I intermittent fast with a 3-4 hour eating window typically 5-6 days a week. One day a week I eat in a 8 hour window.

I do monthly longer fasts. My goal is a week but so far I’ve only done 80 hours.

I’ve read it is imperative one not do this until having metabolic flexibility.

I agree Jason Fung is a great resource.

I like to listen to Dr. Mindy Pelz.

This is a screen shot of a comment from a YT video.

Comment

[hmm777 in reply to Hidden]

I don't take any minerals or electrolytes while fasting other than Morton's Lite salt (which is 50% regular salt and 50% potassium salt). I am considering adding magnesium next time.

I don't recall any discussion of metabolic flexibility (which I assume means some sort of acquired facility in smoothly shifting from normal glucose-based metabolism to ketosis and back) in Fung or Mattson's work and would be interesting in reading about that, if you can recall some sources. My first long fast was 7 days, with no prep other than my usual intermittent fasting, and it went very well, so I have just stuck to this length out of habit. (However, see below for a comment on addition dietary prep that I have adopted over time.)

Couple more points that are not specifically responsive to your question but might be of interest:

- In the past I have always continued my exercise program (mostly heavy weightlifting) during extended fasts in order to preserve muscle mass, albeit with slightly reduced volume. That won't be the case next time because I am still recovering from a significant back injury. The interesting thing is that, contrary to what you'd expect, heavy weightlifting (at least at low volume) was not a problem after a week without food.

- I have learned that it is helpful yo taper off my regular diet, which includes lots of carbs, to a low-carb diet a few days before a fast to shorten the portion of the fast during which my body is consuming glycogen, the idea being to enter ketosis sooner. That said, my understanding is that while ketosis is necessary for the benefits of a true fast it is only part of the story, otherwise you would get identical results from a true no-carb keto diet and fasting and this is not the case. So the idea here is for the beneficial effects of the full fast (vs merely a keto diet) to begin as soon as possible after I stop eating, which means getting in or near ketosis before the fast begins.

[Astra7]

Cake is the problem. How can you turn down cake that people have made specially for you? My keto diet lasted exactly two days, and my keto app is very disappointed with me.🙁

[PDTom]

I've been doing intermittent fasting for over a year. I only eat between 12pm and 8pm. Far too much is eaten these days! My explanation: If I give you $1,000 every day, your pockets will eventually be full of loose change. To get rid of this, I have to stop giving you $1,000. that's how it is with fasting! The body uses up all the garbage and excretes it!

In the course of a study, an American working group transplanted a series of aggressive human tumors (melanoma, glioblastoma, breast cancer) into mice - after about 3-5 months all the mice had died. In another experiment, fasting was then combined with chemotherapy, and depending on the type of tumor, around 50% of the mice were cured. She also no longer continued metastases and achieved a life expectancy that is normal for mice.

The fasting process not only attacks and sensitizes the tumor to chemotherapy (a tumor is programmed to grow and therefore needs it), but also protects the rest of the mouse's nutritional cells against the negative effects of chemotherapy. Fasting alone was about as effective against the tumor in the mice as chemotherapy alone. Only the combination of both strategies leads to healing in this attempt.

[PDTom]

The Russians have a lot of experience with fasting and documented everything at the time. I once saw a documentary that was very interesting! Unfortunately, the documentary is only available in German. You would have to look for an English version in the boarding school...

My grandmother is over 90 years old, I believe that the people who starved in the war are getting older because they were forced to fast. We've lost our natural sense of hunger. We are constantly being offered food! Snacks, etc... Alcohol! Ud really bad - sugar !!!!!!!!! Carbohydrates!!!! All that wheat shit! Dairy products!!!! Also very bad!

Check out "The Milk System"... or "Hope for all"

[Hidden]

DISCLAIMER: This might not work for you.

My PD first became recognizable to me on June 20, 2021. I have 'not' been to a doctor because at this point in my PD -- there's nothing a doctor can do.

99.999% of my tremors are 'internal.' Thousands daily. Foot cramping also.

Most particularly disturbing were my "eyelid tremors" for which I went to an ophthalmologist. He was not helpful.

I live in a very sunny climate so it's easy for me to get sun daily. I try to get at least 15 minutes each side, daily. Sometimes (like today) I do 30 minutes each side.

Today is day #28 that I have been on the O.M.A.D. (one meal a daily) diet.

I encourage you to visit YouTube and search for "Dr Berg Parkinson's Disease" and his videos on autophagy. I also recommend Dr. Sten Ekberg's channel, as well.

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"Dysfunctional autophagy has been shown to contribute to the development of neurodegenerative diseases, including Alzheimer, Parkinson and Huntington disease (reviewed in Menzies et al., 2015). In the absence of autophagy, persistence and defective clearance of misfolded proteins and protein aggregates result in progressive neurodegeneration. "

frontiersin.org/articles/10....

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MY MIRACLE RESULTS!

99.999% of my eyelid tremors are GONE.

99.999% of my internal face tremors are GONE.

My foot cramps (but I do a daily regimen of using my foot and calf massager) are 99.999% GONE.

My tremors in my arms, chest, stomach, and legs -- about the same.

But remember -- I've only been doing my fasting for one month!

Yesterday I extended my fast to 46 hours to see if I could 'count' a reduction in resting arm tremors. No luck on that.... so far.

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NOTE: I am taking over 40 different supplements daily. But I did not see any results from those... But I DEFINITELY see results from sunlight + O.M.A.D. + autophagy.

Good luck for improved health to all of you!

thank you for reading this post

[PDWarrior1900]

I have early PD. I have been on the O.M.A.D. (one meal a day ... which I eat within a 90 minute period) for 158 days. In conjunction with this diet I am engaging with several other therapies. So it is impossible to tell which 'one' or 'ones' are doing me any good. I am LOSING WEIGHT (great!) on the O.M.A.D. diet.