Somebody asked me to look at Wasabi (and I can't remember who) for PD

[Bolt_Upright]

Wasabi has a lot in common with Sulforaphane. That is what I know so far.

DNA Microarray Highlights Nrf2-Mediated Neuron Protection Targeted by Wasabi-Derived Isothiocyanates in IMR-32 Cells 2016 ncbi.nlm.nih.gov/labs/pmc/a...

(SFN is Sulforaphane. 6-MSITC, and 6-MTITC are Wasabi)

To investigate the neuroprotective effects of SFN, 6-MSITC, and 6-MTITC, we investigated the genes coding for proteins involved in apoptosis regulations. Microarray data revealed that the expressions of proapoptosis genes were unaltered by ITC treatment (data not shown). Pre-experiment data also showed that ITCs could protect IMR-32 cells from oxidative stress induced by H2O2 (data not shown). This implies that ITCs do not induce neuronal cell death. Thus, we profiled the effects of SFN, 6-MSITC, and 6-MTITC on the expression of genes mediated by Nrf2 pathway (Table 4). They were classified into five categories including (a) the genes coding upstream regulators, (b) the genes coding antioxidant proteins, (c) the genes coding metabolizing enzymes and detoxifying protein genes, (d) the genes coding chaperone and stress response protein genes, and (e) the genes coding ubiquitination and proteosomal degradation protein. We found that the gene expression of most of the anti oxidant proteins and metabolizing enzymes from 6-MSITC and 6-MTITC treatment was higher than SFN. These are ferritin heavy polypeptide 1 (FTH1), ferritin light polypeptide (FTL), glutathione reductase (GSR), HO-1, NQO1, sequestosome 1 (SQSTM1), and thioredoxin reductase 1 (TXNRD1) for the antioxidant proteins and enzymes. We identified aldo–keto reductase family 1 member C1, C2, C3 (AKR1C1, AKR1C2, AKR1C3), and glutamate-cysteine ligase modifier subunit (GCLM) for metabolizing enzymes. We found that 6-MSITC and 6-MTITC have greater capacity to induce the expressions of genes associated with the Nrf2 pathway in neuron cells.

[Millbrook]

Just came across this Bolt. It was me

[PDTom]

Hydrogen peroxide initiates oxidative stress and proteomic alterations in meningothelial cells

nature.com/articles/s41598-...